Adenocarcinoma of the lung causes: Difference between revisions
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{{CMG}}; {{AE}} {{SC}} | {{CMG}}; {{AE}} {{SC}} | ||
==Overview== | ==Overview== | ||
Adenocarcinoma of the lung may caused by genetic mutations, including [[epidermal growth factor receptor|EGFR]] (7p11), [[KRAS]] (12p12), [[BRAF]] (7q34), and PIK3CA (3q26).<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref> | |||
==Causes== | ==Causes== | ||
| Line 10: | Line 10: | ||
:* [[epidermal growth factor receptor|EGFR]] (7p11) | :* [[epidermal growth factor receptor|EGFR]] (7p11) | ||
:* [[KRAS]] (12p12) | :* [[KRAS]] (12p12) | ||
:* [[BRAF]] (7q34) | :* [[BRAF]] (7q34) | ||
:* PIK3CA (3q26) | :* PIK3CA (3q26) | ||
:* ERBB2 (17q12) | :* ERBB2 (17q12) | ||
:* Translocation EML4/[[anaplastic lymphoma kinase|ALK]] | |||
:* Tyrosine kinase fusions | :* Tyrosine kinase fusions | ||
::* ALK (2p23), ROS1 (6q22), and RET (10q11) | ::* ALK (2p23), ROS1 (6q22), and RET (10q11) | ||
Revision as of 19:52, 14 December 2015
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Adenocarcinoma of the Lung Microchapters |
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Differentiating Adenocarcinoma of the Lung from other Diseases |
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Adenocarcinoma of the lung causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Adenocarcinoma of the lung may caused by genetic mutations, including EGFR (7p11), KRAS (12p12), BRAF (7q34), and PIK3CA (3q26).[1]
Causes
Genetic mutations
- Genes involved in the pathogenesis of adenocarcinoma of the lung include:[2]
- EGFR (7p11)
- KRAS (12p12)
- BRAF (7q34)
- PIK3CA (3q26)
- ERBB2 (17q12)
- Translocation EML4/ALK
- Tyrosine kinase fusions
- ALK (2p23), ROS1 (6q22), and RET (10q11)
References
- ↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
- ↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.