Myelodysplastic syndrome laboratory findings: Difference between revisions
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*Monosomy 7 | *Monosomy 7 | ||
*Monosomy 8 | *Monosomy 8 | ||
===Bone marrow aspiration and biopsy=== | ===Bone marrow aspiration and biopsy=== | ||
On bone marrow biopsy, findings of myelodysplastic syndrome include:<ref name="TricotWolf-Peeters1984">{{cite journal|last1=Tricot|first1=G.|last2=Wolf-Peeters|first2=C. De|last3=Hendrickx|first3=B.|last4=Verwilghen|first4=R. L.|title=Bone marrow histology in myelodysplastic syndromes.|journal=British Journal of Haematology|volume=57|issue=3|year=1984|pages=423–430|issn=0007-1048|doi=10.1111/j.1365-2141.1984.tb02916.x}}</ref> | On bone marrow biopsy, findings of myelodysplastic syndrome include:<ref name="TricotWolf-Peeters1984">{{cite journal|last1=Tricot|first1=G.|last2=Wolf-Peeters|first2=C. De|last3=Hendrickx|first3=B.|last4=Verwilghen|first4=R. L.|title=Bone marrow histology in myelodysplastic syndromes.|journal=British Journal of Haematology|volume=57|issue=3|year=1984|pages=423–430|issn=0007-1048|doi=10.1111/j.1365-2141.1984.tb02916.x}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.[1]
Laboratory Findings
Laboratory findings consistent with the diagnosis of myelodysplastic syndrome include abnormal complete blood count, peripheral blood smear, cytogenetic analysis, immunohistochemistry, and bone marrow biopsy.[1]
Complete Blood Count
On complete blood count, characteristic findings of myelodysplastic syndrome include:[1]
Peripheral Blood Smear
On peripheral blood smear, characteristic findings of myelodysplastic syndrome include:[2][3][4][5]
- Macro-ovalocytes
- Basophilic stippling
- Howell-Jolly body
- Acquired or pseudo-Pelger-Huët anomaly
Cytogenetic analysis
On cytogenetic analysis, characteristic findings of myelodysplastic syndrome include:[6][7]
- Deletions within the long arm of chromosome 5
- Deletions within the short arm of chromosome 17
- Monosomy 7
- Monosomy 8
Bone marrow aspiration and biopsy
On bone marrow biopsy, findings of myelodysplastic syndrome include:[8]
- Abnormal erythropoiesis
- Abnormal myelopoiesis
References
- ↑ 1.0 1.1 1.2 Tests to examine and diagnose myelodysplastic syndromes. National Cancer Institute 2015. http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq. Accessed on December 14, 2015
- ↑ Causes of macrocytosis. Wikipedia (2015). https://en.wikipedia.org/wiki/Macrocytosis. Accessed on December 14, 2015
- ↑ Basophilic stippling. Wikipedia (2015). https://en.wikipedia.org/wiki/Basophilic_stippling. Accessed on December 14, 2015
- ↑ Causes of Howell-Jolly body. Wikipedia (2015). https://en.wikipedia.org/wiki/Howell%E2%80%93Jolly_body. Accessed on December 14, 2015
- ↑ Acquired or pseudo-Pelger-Huët anomaly. Wikipedia (2015). https://en.wikipedia.org/wiki/Pelger%E2%80%93Huet_anomaly. Accessed on December 14, 2015
- ↑ Cytogenetics of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
- ↑ Haase, Detlef (2008). "Cytogenetic features in myelodysplastic syndromes". Annals of Hematology. 87 (7): 515–526. doi:10.1007/s00277-008-0483-y. ISSN 0939-5555.
- ↑ Tricot, G.; Wolf-Peeters, C. De; Hendrickx, B.; Verwilghen, R. L. (1984). "Bone marrow histology in myelodysplastic syndromes". British Journal of Haematology. 57 (3): 423–430. doi:10.1111/j.1365-2141.1984.tb02916.x. ISSN 0007-1048.