Langerhans cell histiocytosis pathophysiology: Difference between revisions
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==Genetics== | ==Genetics== | ||
==Associated Conditions== | ==Associated Conditions== | ||
==Gross Pathology== | ==Gross Pathology== | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:<ref name=microscopy>Microscopic features of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015</ref> | On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:<ref name=microscopy>Microscopic features of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015</ref> | ||
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*S100 positive | *S100 positive | ||
*CD207 (AKA Langerin) positive | *CD207 (AKA Langerin) positive | ||
==Electron Microscopy== | |||
On electron microscopy, findings of langerhans cell histiocytosis include:<ref name=librepathologyEM>Electron microscopy of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015</ref> | |||
*Birbeck granules | |||
*Cell membrane invagination | |||
*Electron dense, cytoplasmic tennis racket-like body | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:53, 21 December 2015
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Langerhans cell histiocytosis Microchapters |
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Differentiating Langerhans cell histiocytosis from other Diseases |
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Langerhans cell histiocytosis pathophysiology On the Web |
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Risk calculators and risk factors for Langerhans cell histiocytosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Pathophysiology
Pathogenesis
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:[1]
- Langerhans cells histiocytes
- Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.
- Nucleus may look like a "coffee bean", that is have nuclear grooves, appearance dependent on the rotation of the nucleus.
- May be called "buttock cells".
Immunohistochemistry
Langerhans cell histiocytosis is demonstrated by positivity to:[2]
- CD1a positive
- S100 positive
- CD207 (AKA Langerin) positive
Electron Microscopy
On electron microscopy, findings of langerhans cell histiocytosis include:[3]
- Birbeck granules
- Cell membrane invagination
- Electron dense, cytoplasmic tennis racket-like body
References
- ↑ Microscopic features of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015
- ↑ Immunohistochemistry of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015
- ↑ Electron microscopy of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015