Splenic marginal zone lymphoma physical examination: Difference between revisions

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__NOTOC__
__NOTOC__
{{Splenic marginal zone lymphoma}}
{{Splenic marginal zone lymphoma}}
{{CMG}}
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Overview==
== Physical Examination ==
Common physical examination findings of splenic marginal zone lymphoma include [[fever]], [[rash]], [[ulcer]], [[splenomegaly]], [[hepatomegaly]], chest tenderness, abdomen tenderness, bone tenderness, [[Lymphadenopathy|peripheral lymphadenopathy]], and [[Lymphadenopathy|central lymphadenopathy]].<ref name= seer>Splenic marginal zone lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd5327/ Accessed on December 22, 2015 </ref>
With splenic involvement a ''sine qua non'' for SMZL, [[splenomegaly]] is seen in almost all patients, commonly without lymphadenopathy.<ref name="who1">[http://www.iarc.fr/WHO-BlueBooks/BBwebsite/bb3.html] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): '''World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues.''' IARC Press: Lyon 2001 </ref> Reactive germinal centers in [[splenic]] [[white pulp]] are replaced by small neoplastic [[lymphocytes]] that efface the mantle zone and ultimately blend in with the [[marginal zone]] with occasional larger neoplastic cells that resemble blasts.<ref name="mol1"> [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7573673&query_hl=9&itool=pubmed_ExternalLink]
==Physical Examination <ref name= seer>Splenic marginal zone lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd5327/ Accessed on December 22, 2015 </ref>==
Mollejo M, Menarguez J, Lloret E, Sanchez A, Campo E, Algara P, Cristobal E, Sanchez E, Piris MA.
===Temperature===
"Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases." '''Am J Surg Pathol'''. 1995 Oct;19(10):1146-57.
* [[Fever]] is often present
PMID: 7573673</ref><ref name="jaf1">
===Skin===
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=6638043&query_hl=11&itool=pubmed_ExternalLink]
* [[Rash]]
Jaffe ES, Costa J, Fauci AS, Cossman J, Tsokos M. "Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis." '''Am J Med'''. 1983 Nov;75(5):741-9. PMID: 6638043</ref> The [[red pulp]] is always involved, with both nodules of larger neoplastic cells and sheets of the small neoplastic [[lymphocytes]]. Other features that may been seen include [[sinus]] invasion, epithelial histocytes, and plasmacytic differentiation of neoplastic cells.
* [[Ulcer]]
===Neck===
* [[Lymphadenopathy|Cervical lymphadenopathy]]
===Thorax===
* Thoracic masses suggestive of [[Lymphadenopathy|central lymphadenopathy]]
* Chest tenderness
===Abdomen===
* [[Abdominal mass]]es suggestive of [[Lymphadenopathy|central lymphadenopathy]]
* [[Splenomegaly]]
* [[Hepatomegaly]]  
* Abdomen tenderness
===Extremities===
* [[Lymphadenopathy|Peripheral lymphadenopathy]]
* Bone tenderness


==References==
==References==
{{reflist|2}}
{{reflist|2}}
{{WH}}
{{WH}}
{{WS}}
{{WS}}
 
[[Category:Hematology]]
[[Category:Disease]]
[[Category:Types of cancer]]

Revision as of 16:41, 22 December 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Common physical examination findings of splenic marginal zone lymphoma include fever, rash, ulcer, splenomegaly, hepatomegaly, chest tenderness, abdomen tenderness, bone tenderness, peripheral lymphadenopathy, and central lymphadenopathy.[1]

Physical Examination [1]

Temperature

Skin

Neck

Thorax

Abdomen

Extremities

References

  1. ↑ 1.0 1.1 Splenic marginal zone lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd5327/ Accessed on December 22, 2015

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