Ameloblastoma medical therapy: Difference between revisions
Jump to navigation
Jump to search
Simrat Sarai (talk | contribs) No edit summary |
Simrat Sarai (talk | contribs) No edit summary |
||
| Line 3: | Line 3: | ||
{{CMG}}{{AE}}{{Simrat}} | {{CMG}}{{AE}}{{Simrat}} | ||
==Overview== | ==Overview== | ||
The mainstay of therapy for ameloblastoma is surgery. The predominant therapy for ameloblastoma is surgical resection. Adjunctive chemotherapy/radiation/chemoradiation may be required. | The mainstay of therapy for ameloblastoma is surgery. The predominant therapy for ameloblastoma is surgical resection. Adjunctive chemotherapy/radiation/chemoradiation may be required.<ref name="wiki"> Ameloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Ameloblastoma Accessed on December 25, 2015</ref > | ||
==Medical Therapy== | ==Medical Therapy== | ||
| Line 19: | Line 19: | ||
*Although ameloblastoma is not a cancer that actually invades adjacent tissues, it is suspected to spread to adjacent areas of the jaw bone via marrow space. Thus, wide surgical margins that are clear of disease are required for a good prognosis. This is very much like surgical treatment of cancer. | *Although ameloblastoma is not a cancer that actually invades adjacent tissues, it is suspected to spread to adjacent areas of the jaw bone via marrow space. Thus, wide surgical margins that are clear of disease are required for a good prognosis. This is very much like surgical treatment of cancer. | ||
*Often, treatment requires excision of entire portions of the jaw. Surgery is the only effective method for removing the excess tissue growth. A wide surgical excision is often required; in majority of cases, a part of the bone beneath the growth must be removed as well. Surgical curettage of the bone tumor is another treatment modality- although, there is a higher chance of recurrence with this treatment method. | *Often, treatment requires excision of entire portions of the jaw. Surgery is the only effective method for removing the excess tissue growth. A wide surgical excision is often required; in majority of cases, a part of the bone beneath the growth must be removed as well. Surgical curettage of the bone tumor is another treatment modality- although, there is a higher chance of recurrence with this treatment method. | ||
*Since, surgery is a highly effective method to treat ameloblastoma, in most situations, chemotherapy and radiation treatment is not preferred. Facial reconstructive surgeries may be required, after removal of the tumor. Radiation is ineffective in many cases of ameloblastoma. There have also been reports of sarcoma being induced as the result of using radiation to treat ameloblastoma. Chemotherapy is also often ineffective. However, there is some controversy regarding this and some indication that some ameloblastomas might be more responsive to radiation that previously thought. | *Since, surgery is a highly effective method to treat ameloblastoma, in most situations, chemotherapy and radiation treatment is not preferred. Facial reconstructive surgeries may be required, after removal of the tumor. Radiation is ineffective in many cases of ameloblastoma. There have also been reports of sarcoma being induced as the result of using radiation to treat ameloblastoma. Chemotherapy is also often ineffective. However, there is some controversy regarding this and some indication that some ameloblastomas might be more responsive to radiation that previously thought.<ref name="wiki"> Ameloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Ameloblastoma Accessed on December 25, 2015</ref > | ||
==References== | ==References== | ||
Revision as of 18:21, 27 December 2015
|
Ameloblastoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Ameloblastoma medical therapy On the Web |
|
American Roentgen Ray Society Images of Ameloblastoma medical therapy |
|
Risk calculators and risk factors for Ameloblastoma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
The mainstay of therapy for ameloblastoma is surgery. The predominant therapy for ameloblastoma is surgical resection. Adjunctive chemotherapy/radiation/chemoradiation may be required.[1]
Medical Therapy
Management of ameloblastoma has been controversial due to the unique biological behavior of ameloblastoma as a slow-growing, locally invasive tumor with a high rate of recurrence. Recurrence rates of ameloblastoma are reportedly as high as 75-90% after conservative treatment and 15-25% after radical treatment. Therefore, wide resection of the jaw in accordance with the treatment of malignant tumors is usually recommended for ameloblastomas. Treatment of mandibular ameloblastoma continues to be controversial. It can change with various factors listed below. Treatment consists of wide resection, curettage and enucleation. Where the lower border of the mandible is not affected by the tumor conservative treatment of ameloblastoma by enucleation and bone curettage is done.[2]
Treatment decisions for ameloblastoma are based on the following factors:[2]
- Anatomical location
- Clinical behavior of the tumor
- Age
- General state of health of the patient
- Size
- Histologic variant
- Clinicoradiologic variant
- Surgery is the most common treatment of this tumor. Excision of normal tissue near the tumor margin is often required, because of the invasive nature of the growth. ameloblastoma has tendency to spread to adjacent bony and sometimes soft tissues without metastasizing.
- Although ameloblastoma is not a cancer that actually invades adjacent tissues, it is suspected to spread to adjacent areas of the jaw bone via marrow space. Thus, wide surgical margins that are clear of disease are required for a good prognosis. This is very much like surgical treatment of cancer.
- Often, treatment requires excision of entire portions of the jaw. Surgery is the only effective method for removing the excess tissue growth. A wide surgical excision is often required; in majority of cases, a part of the bone beneath the growth must be removed as well. Surgical curettage of the bone tumor is another treatment modality- although, there is a higher chance of recurrence with this treatment method.
- Since, surgery is a highly effective method to treat ameloblastoma, in most situations, chemotherapy and radiation treatment is not preferred. Facial reconstructive surgeries may be required, after removal of the tumor. Radiation is ineffective in many cases of ameloblastoma. There have also been reports of sarcoma being induced as the result of using radiation to treat ameloblastoma. Chemotherapy is also often ineffective. However, there is some controversy regarding this and some indication that some ameloblastomas might be more responsive to radiation that previously thought.[1]
References
- ↑ 1.0 1.1 Ameloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Ameloblastoma Accessed on December 25, 2015
- ↑ 2.0 2.1 Gümgüm S, Hoşgören B (2005). "Clinical and radiologic behaviour of ameloblastoma in 4 cases". J Can Dent Assoc. 71 (7): 481–4. PMID 16026635.