Glomus tumor pathophysiology: Difference between revisions
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**Mutations are associated with multiple deletions in the glomulin gene of chromosome 1p21-22.<ref name=rs>Glomus tumor. Wikipedia. https://en.wikipedia.org/wiki/Glomus_tumor Accessed on January 7, 2016.</ref> <ref name="pmid18788860">{{cite journal| author=Gombos Z, Zhang PJ| title=Glomus tumor. | journal=Arch Pathol Lab Med | year= 2008 | volume= 132 | issue= 9 | pages= 1448-52 | pmid=18788860 | doi=10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18788860 }} </ref> | **Mutations are associated with multiple deletions in the glomulin gene of chromosome 1p21-22.<ref name=rs>Glomus tumor. Wikipedia. https://en.wikipedia.org/wiki/Glomus_tumor Accessed on January 7, 2016.</ref> <ref name="pmid18788860">{{cite journal| author=Gombos Z, Zhang PJ| title=Glomus tumor. | journal=Arch Pathol Lab Med | year= 2008 | volume= 132 | issue= 9 | pages= 1448-52 | pmid=18788860 | doi=10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18788860 }} </ref> | ||
**Inheritance is autosomal dominant with incomplete penetrance.<ref name=rs>Glomus tumor. Wikipedia. https://en.wikipedia.org/wiki/Glomus_tumor Accessed on January 7, 2016.</ref> <ref name="pmid18788860">{{cite journal| author=Gombos Z, Zhang PJ| title=Glomus tumor. | journal=Arch Pathol Lab Med | year= 2008 | volume= 132 | issue= 9 | pages= 1448-52 | pmid=18788860 | doi=10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18788860 }} </ref> | **Inheritance is autosomal dominant with incomplete penetrance.<ref name=rs>Glomus tumor. Wikipedia. https://en.wikipedia.org/wiki/Glomus_tumor Accessed on January 7, 2016.</ref> <ref name="pmid18788860">{{cite journal| author=Gombos Z, Zhang PJ| title=Glomus tumor. | journal=Arch Pathol Lab Med | year= 2008 | volume= 132 | issue= 9 | pages= 1448-52 | pmid=18788860 | doi=10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18788860 }} </ref> | ||
==Associated Conditions== | |||
*Glomus tumors of the fingers and toes may be associated with neurofibromatosis type 1. | |||
==Gross Pathology== | ==Gross Pathology== | ||
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*On microscopic histopathological analysis, characteristic findings of glomus tumor include:<ref name=pm>Glomus tumor. Radiopedia. http://radiopaedia.org/articles/glomangioma Accessed on January 7, 2016.</ref> | *On microscopic histopathological analysis, characteristic findings of glomus tumor include:<ref name=pm>Glomus tumor. Radiopedia. http://radiopaedia.org/articles/glomangioma Accessed on January 7, 2016.</ref> | ||
**Branching vascular channels | **Branching vascular channels | ||
**Aggregates of | **Aggregates of specialized glomus cells | ||
**Inconspicuous to well-defined nucleoli | **Inconspicuous to well-defined nucleoli | ||
Revision as of 13:37, 8 January 2016
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Glomus tumor Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Glomus tumor pathophysiology On the Web |
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American Roentgen Ray Society Images of Glomus tumor pathophysiology |
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Risk calculators and risk factors for Glomus tumor pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Glomus tumor arises from modified smooth muscle cells of glomus body (or glomus apparatus). Glomus body is a neuromyoarterial plexus in the dermis of skin that is normally involved in thermoregulation.[1] Gene involved in the pathogenesis of familial glomangioma is ''glomulin'' (''GLMN'') gene.[2] *On gross pathology, small (usually less than 1 cm), bluish or whitish, well circumscribed, solitary nodules are characteristic findings of glomus tumor.[1] On microscopic histopathological analysis, branching vascular channels and aggregates of specialised glomus cells are characteristic findings of glomus tumor.[3]
Pathophysiology
- Glomus tumor arises from modified smooth muscle cells of glomus body (or glomus apparatus).[1]
- Glomus body is a neuromyoarterial plexus in the dermis of skin that is normally involved in thermoregulation.
Genetics
- Familial glomangioma is a variant of glomus tumor where the patient presents with multiple glomus tumors.[1] [2]
- Gene involved in the pathogenesis of familial glomangioma is ''glomulin'' (''GLMN'') gene.[1] [2]
Associated Conditions
- Glomus tumors of the fingers and toes may be associated with neurofibromatosis type 1.
Gross Pathology
- On gross pathology, small (usually less than 1 cm), bluish or whitish, well circumscribed, solitary nodules are characteristic findings of glomus tumor.[1]
- Multiple glomus tumors are usually less circumscribed and less solid than the solitary glomus tumors.[2]
Microscopic Findings
- On microscopic histopathological analysis, characteristic findings of glomus tumor include:[3]
- Branching vascular channels
- Aggregates of specialized glomus cells
- Inconspicuous to well-defined nucleoli
-
![Intermediate magnification micrograph of a glomus tumor. H&E stain.[4]](/images/3/39/Glomus_tumour_-_intermed_mag.jpg)
Intermediate magnification micrograph of a glomus tumor. H&E stain.[4]
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![High magnification micrograph of a glomus tumor. H&E stain.[4]](/images/d/d8/1200px-Glomus_tumour_-_high_mag.jpg)
High magnification micrograph of a glomus tumor. H&E stain.[4]
-
![Very high magnification micrograph of a glomus tumor. H&E stain.[4]](/images/4/48/1200px-Glomus_tumour_-_2_-_very_high_mag.jpg)
Very high magnification micrograph of a glomus tumor. H&E stain.[4]
![Intermediate magnification micrograph of a glomus tumor. H&E stain.[4]](/index.php/File:Glomus_tumour_-_intermed_mag.jpg)
![High magnification micrograph of a glomus tumor. H&E stain.[4]](/index.php/File:1200px-Glomus_tumour_-_high_mag.jpg)
![Very high magnification micrograph of a glomus tumor. H&E stain.[4]](/index.php/File:1200px-Glomus_tumour_-_2_-_very_high_mag.jpg)
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Glomus tumor. Wikipedia. https://en.wikipedia.org/wiki/Glomus_tumor Accessed on January 7, 2016.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gombos Z, Zhang PJ (2008). "Glomus tumor". Arch Pathol Lab Med. 132 (9): 1448–52. doi:10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2. PMID 18788860.
- ↑ 3.0 3.1 Glomus tumor. Radiopedia. http://radiopaedia.org/articles/glomangioma Accessed on January 7, 2016.
- ↑ 4.0 4.1 4.2 Glomus tumor. Wikimedia commons. https://commons.wikimedia.org/wiki/File:Glomus_tumour_-_very_high_mag.jpg#/media/File:Glomus_tumour_-_intermed_mag.jpg Accessed on January 7, 2016.
