Evans syndrome pathophysiology: Difference between revisions
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{{Evans syndrome}} | {{Evans syndrome}} | ||
==Overview== | |||
==Pathogenesis== | |||
Evans syndrome is an [[autoimmune disease]] in which an individual's [[antibodies]] attack their own [[red blood cell]]s and [[platelet]]s.<ref name="pmid14782741">{{cite journal |author=Evans RS, Takahashi K, Duane RT, Payne R, Liu C |title=Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology |journal=A.M.AARRAYrchives of internal medicine |volume=87 |issue=1 |pages=48–65 |year=1951 |pmid=14782741 |doi=}}</ref> Both of these events may occur simultaneously or one may follow on from the other.<ref name="pmid16398647">{{cite journal |author=Norton A, Roberts I |title=Management of Evans syndrome |journal=Br. J. Haematol. |volume=132 |issue=2 |pages=125–37 |year=2006 |pmid=16398647 |doi=10.1111/j.1365-2141.2005.05809.x}}</ref> | |||
* Its overall pathology resembles a combination of [[autoimmune hemolytic anemia]] and [[idiopathic thrombocytopenic purpura]].<ref name="pmid14782741"/> Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry [[oxygen]] and [[carbon dioxide]] are destroyed by an autoimmune process. Idiopathic thrombocytopenic purpura is a condition in which platelets are destroyed by an autoimmune process. Platelets are a component of blood that contribute to the formation of [[blood clot]]s in the body to prevent bleeding. | |||
==Genetics== | |||
==Associated Conditions== | |||
==Gross Pathology== | |||
==Microscopic Pathology== | |||
==References== | ==References== | ||
Revision as of 17:27, 10 January 2016
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Overview
Pathogenesis
Evans syndrome is an autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets.[1] Both of these events may occur simultaneously or one may follow on from the other.[2]
- Its overall pathology resembles a combination of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura.[1] Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen and carbon dioxide are destroyed by an autoimmune process. Idiopathic thrombocytopenic purpura is a condition in which platelets are destroyed by an autoimmune process. Platelets are a component of blood that contribute to the formation of blood clots in the body to prevent bleeding.
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
References
- ↑ 1.0 1.1 Evans RS, Takahashi K, Duane RT, Payne R, Liu C (1951). "Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology". A.M.AARRAYrchives of internal medicine. 87 (1): 48–65. PMID 14782741.
- ↑ Norton A, Roberts I (2006). "Management of Evans syndrome". Br. J. Haematol. 132 (2): 125–37. doi:10.1111/j.1365-2141.2005.05809.x. PMID 16398647.