Bordetella pertussis: Difference between revisions

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Revision as of 17:07, 14 January 2016

This page is about microbiologic aspects of the organism(s). For clinical aspects of the disease, see Pertussis.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]

Overview

Bordetella pertussis is a Gram-negative, aerobic, non-motile, non-spore-forming coccobacillus. It is the pathogen responsible for pertussis (whooping cough). Unlike B. bronchiseptica, B. pertussis is not motile. Humans are the only known reservoir for B. pertussis.

Bodetella pertussis

Higher Order Taxa

Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Bordetella
Species: B. pertussis

Genome

The genome of B. pertussis consists of 1 circular chromosome and plasmids.

The circular chromosome contains 3867 genes and 4,086,189 nucleotides.^[1]
The IncP-1 beta plasmid pBP136 carries 46 ORFs and contains 41,268 bp nucleotides.^[1]

Structure

B. pertussis is a Gram-negative, aerobic, non-spore forming coccobacillus.
Compared with Bordetella bronchiseptica, B. pertussis is non-motile.
It contains an outer membrane, an inner membrane, and a periplasmic space between the 2 membranes.^[2]
The rough lipopolysaccharide on the outer membrane (also called lipooligosaccharide) contains a phosphate composition (containing lipid X) that is different from other bacterial lipopolysaccharides (containing lipid A). The B. pertussis outer membrane is thus a distinguishing feature of B. pertussis.^[2]

References

↑ ^1.0 ^1.1 Kamachi K, Sota M, Tamai Y, Nagata N, Konda T, Inoue T; et al. (2006). "Plasmid pBP136 from Bordetella pertussis represents an ancestral form of IncP-1beta plasmids without accessory mobile elements". Microbiology. 152 (Pt 12): 3477–84. doi:10.1099/mic.0.29056-0. PMID 17159199.
↑ ^2.0 ^2.1 Harvill ET, Preston A, Cotter PA, Allen AG, Maskell DJ, Miller JF (2000). "Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection". Infect Immun. 68 (12): 6720–8. PMC 97772. PMID 11083787.

Ray, C.G., ed. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
Todar, K. (2008). "Bordetella pertussis and Whooping Cough". Online Textbook of Bacteriology. Retrieved December 11, 2009.

[pmid17159199-1] 1.0 ^1.1 Kamachi K, Sota M, Tamai Y, Nagata N, Konda T, Inoue T; et al. (2006). "Plasmid pBP136 from Bordetella pertussis represents an ancestral form of IncP-1beta plasmids without accessory mobile elements". Microbiology. 152 (Pt 12): 3477–84. doi:10.1099/mic.0.29056-0. PMID 17159199.

[pmid11083787-2] 2.0 ^2.1 Harvill ET, Preston A, Cotter PA, Allen AG, Maskell DJ, Miller JF (2000). "Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection". Infect Immun. 68 (12): 6720–8. PMC 97772. PMID 11083787.

[1]

[2]

@@ Line 26: / Line 26: @@
 *Compared with ''Bordetella bronchiseptica'', ''B. pertussis'' is non-motile.
 *It contains an outer membrane, an inner membrane, and a periplasmic space between the 2 membranes.<ref name="pmid11083787">{{cite journal| author=Harvill ET, Preston A, Cotter PA, Allen AG, Maskell DJ, Miller JF| title=Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection. | journal=Infect Immun | year= 2000 | volume= 68 | issue= 12 | pages= 6720-8 | pmid=11083787 | doi= | pmc=PMC97772 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11083787  }} </ref>
-*The lipopolysaccharide on the outer membrane contains a phosphate composition (lipid X) different from other bacterial outer membranes (lipid A). The ''B. pertussis'' outer membrane is thus a distinguishing feature of ''B. pertussis''.<ref name="pmid11083787">{{cite journal| author=Harvill ET, Preston A, Cotter PA, Allen AG, Maskell DJ, Miller JF| title=Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection. | journal=Infect Immun | year= 2000 | volume= 68 | issue= 12 | pages= 6720-8 | pmid=11083787 | doi= | pmc=PMC97772 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11083787  }} </ref>
+*The rough lipopolysaccharide on the outer membrane (also called lipooligosaccharide) contains a phosphate composition (containing lipid X) that is different from other bacterial lipopolysaccharides (containing lipid A). The ''B. pertussis'' outer membrane is thus a distinguishing feature of ''B. pertussis''.<ref name="pmid11083787">{{cite journal| author=Harvill ET, Preston A, Cotter PA, Allen AG, Maskell DJ, Miller JF| title=Multiple roles for Bordetella lipopolysaccharide molecules during respiratory tract infection. | journal=Infect Immun | year= 2000 | volume= 68 | issue= 12 | pages= 6720-8 | pmid=11083787 | doi= | pmc=PMC97772 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11083787  }} </ref>
 ==References==