Paracoccidioidomycosis natural history, complications and prognosis: Difference between revisions
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**superficial node enlargement | **superficial node enlargement | ||
**deep lymph node enlargement | **deep lymph node enlargement | ||
*The symptoms of PMC chronic usually develop in the third decade of life, eventhough the infection can be acquired in the first decade of life <ref name= | *The symptoms of PMC chronic usually develop in the third decade of life, eventhough the infection can be acquired in the first decade of life <ref name=a>Vargas J, Vargas R. Paracoccidiodomicosis. ''Rev. enferm. infecc. trop.''2009(1):49-56</ref>.... Start with symptoms such as ___. The symptoms of (disease name) typically develop ___ years after exposure to ___. Without treatment, the patient will develop symptoms of ___, which will/ may eventually lead to ___. | ||
===Infection=== | ===Infection=== | ||
*The infection can be adquired in the first decade of life. PMC infection has no manifested symptoms. <ref name="pmid21738969">{{cite journal| author=Fortes MR, Miot HA, Kurokawa CS, Marques ME, Marques SA| title=Immunology of paracoccidioidomycosis. | journal=An Bras Dermatol | year= 2011 | volume= 86 | issue= 3 | pages= 516-24 | pmid=21738969 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21738969 }} </ref> | *The infection can be adquired in the first decade of life. PMC infection has no manifested symptoms. <ref name="pmid21738969">{{cite journal| author=Fortes MR, Miot HA, Kurokawa CS, Marques ME, Marques SA| title=Immunology of paracoccidioidomycosis. | journal=An Bras Dermatol | year= 2011 | volume= 86 | issue= 3 | pages= 516-24 | pmid=21738969 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21738969 }} </ref> | ||
| Line 16: | Line 16: | ||
===Chronic=== | ===Chronic=== | ||
==Complications== | ==Complications== | ||
Paracoccidioidomycosis develops sequelae frequently: | |||
* | *Chronic obstructive pulmonary disease (COPD) | ||
*Adrenal gland | *Pulmonary fibrosis | ||
*dysphonia | *Adrenal gland insufficiency | ||
* | *Superior airway obstruccion (dysphonia and laryngeal lesions) | ||
* | *Difficulty for mouth opening | ||
*Seizures | |||
*Motor deficiency <ref name=b> Wanke B, Aidê M. Chapter 6 - Paracoccidioidomycosis. ''J. bras. pneumol.'' 2009; 35(12):1245-1249 </ref> <ref name=c> Francesconi F, da Silva MT, Costa RL, et al. Long-term outcome of neuroparacoccidioidomycosis treatment. ''Rev Soc Bras Med Trop.'' 2011;44(1):22-25</ref> | |||
==Prognosis== | ==Prognosis== | ||
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Overview
Natural History
- The symptoms of acute/subacute PMC is usually develop in children and young adults, under 35 years. Start with inespecific symptoms such as:
- superficial node enlargement
- deep lymph node enlargement
- The symptoms of PMC chronic usually develop in the third decade of life, eventhough the infection can be acquired in the first decade of life [1].... Start with symptoms such as ___. The symptoms of (disease name) typically develop ___ years after exposure to ___. Without treatment, the patient will develop symptoms of ___, which will/ may eventually lead to ___.
Infection
- The infection can be adquired in the first decade of life. PMC infection has no manifested symptoms. [2]
Acute/subacute
Chronic
Complications
Paracoccidioidomycosis develops sequelae frequently:
- Chronic obstructive pulmonary disease (COPD)
- Pulmonary fibrosis
- Adrenal gland insufficiency
- Superior airway obstruccion (dysphonia and laryngeal lesions)
- Difficulty for mouth opening
- Seizures
- Motor deficiency [3] [4]
Prognosis
References
- ↑ Vargas J, Vargas R. Paracoccidiodomicosis. Rev. enferm. infecc. trop.2009(1):49-56
- ↑ Fortes MR, Miot HA, Kurokawa CS, Marques ME, Marques SA (2011). "Immunology of paracoccidioidomycosis". An Bras Dermatol. 86 (3): 516–24. PMID 21738969.
- ↑ Wanke B, Aidê M. Chapter 6 - Paracoccidioidomycosis. J. bras. pneumol. 2009; 35(12):1245-1249
- ↑ Francesconi F, da Silva MT, Costa RL, et al. Long-term outcome of neuroparacoccidioidomycosis treatment. Rev Soc Bras Med Trop. 2011;44(1):22-25