Mycosis fungoides medical therapy

Cutaneous T cell lymphoma Microchapters
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Overview
Classification Mycosis fungoides Sezary syndrome
Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Medical therapy

There is no cure for CTCL, but there are a variety of treatment options available and some CTCL patients are able to live somewhat normal lives with this cancer, although symptoms can be debilitating and painful, even in earlier stages.

Treatments include: Topical Corticosteroids, Bexarotene Gel, Carmustine(Nitrogen Mustard), Mechlorethamine, Phototherapy (Broad & Narrow Band UVB or PUVA), Local & Total Skin Electron Beam Radiation, Conventional Radiation Therapy, Oral Corticosteroids, Bexarotene (Targretin®) Capsules, Photopheresis, Interferons, Denileukin Diftitox (Ontak®), Alemtuzumab (Campath-1H), Vorinostat (Zolinza®), Methotrexate, Pentostatin & other purine analogues (Fludarabine, 2- deoxychloroadenosine), Liposomal doxorubicin (Doxil®), Gemcitabine (Gemzar®), Cyclophosphamide, oral, Bone marrow/Stem cell, and Allogenic Transplantation.

more TSEB radiation in some cases radiation therapy to bulky tumours or lymph nodes PUVA topical or systemic chemotherapy biological therapy

Read more: http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/cutaneous-t-cell-lymphoma/?region=on#ixzz3xcr1oK2i

Medical therapy for cutaneous T cell lymphoma

Stage	PUVA	Topical chemotherapy	Systemic chemotherapy	Radiotherapy	Biological therapy	Retinoid therapy	Photopheresis
Stage I	May be given by itself or with interferon alfa	May be offered	May be offered	To 1 or 2 skin lesions (local radiation therapy) or to all the skin on the body (TSEB)	May be given by itself or with topical chemotherapy	May be offered	---------
Stage II	May be given by itself or with interferon alfa	May be offered	May be offered	To 1 or 2 skin lesions (local radiation therapy) or to all the skin on the body (TSEB)	May be given by itself or with topical chemotherapy	May be offered	---------
Stage III	May be given by itself or with interferon alfa or systemic chemotherapy	May be offered	May be combined with other skin-focussed therapies	To all the skin on the body (TSEB) As palliative therapy to reduce the size of tumours or relieve symptoms	May be given by itself or with topical chemotherapy	May be offered	May be offered
Stage IV	May be given by itself or with interferon alfa or systemic chemotherapy	May be offered	May be offered	To all the skin on the body (TSEB) As palliative therapy to reduce the size of tumours or relieve symptoms	May be given by itself or with topical chemotherapy	May be offered	May be given by itself or with TSEB
Recurrent cutaneous T cell lymphoma	May be offered	May be offered	May be offered	More TSEB radiation in some cases Radiation therapy to bulky tumours or lymph nodes	May be offered	---------	---------

References

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