Desmoid tumor pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
==Pathophysiology== | ==Pathophysiology== | ||
Their exact aetiology remains uncertain, although they are frequently associated with previous trauma or surgical incision. On the molecular level, desmoids are characterised by mutations in the [[β-catenin gene]], CTNNB1, or the adenomatous polyposis coli gene, APC.<ref>Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour</ref> | Their exact aetiology remains uncertain, although they are frequently associated with previous trauma or surgical incision. On the molecular level, desmoids are characterised by mutations in the [[β-catenin gene]], CTNNB1, or the adenomatous polyposis coli gene, APC.<ref>Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour</ref> | ||
===Associated Diseases== | |||
some cases have been associated with oestrogen therapy ref | |||
Gardner syndrome | |||
in the case of mesenteric desmoid they are seen either sporadically or in association with familial polyposis coli syndrome (FAP): 9-18 of FAP cases may have a desmoid tumour 8 | |||
===Location=== | |||
Frequent locations in the abdomen are the abdominal wall, the root of the mesentery and the retroperitoneum. | |||
Revision as of 20:12, 19 January 2016
|
Desmoid tumor Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Pathophysiology
Their exact aetiology remains uncertain, although they are frequently associated with previous trauma or surgical incision. On the molecular level, desmoids are characterised by mutations in the β-catenin gene, CTNNB1, or the adenomatous polyposis coli gene, APC.[1]
=Associated Diseases
some cases have been associated with oestrogen therapy ref Gardner syndrome in the case of mesenteric desmoid they are seen either sporadically or in association with familial polyposis coli syndrome (FAP): 9-18 of FAP cases may have a desmoid tumour 8
Location
Frequent locations in the abdomen are the abdominal wall, the root of the mesentery and the retroperitoneum.
Reference
- ↑ Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour