Williams-Campbell syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Cartilage deficiency

Overview

Williams–Campbell syndrome is a disease of the airways where cartilage in the bronchi is defective. This leads to collapse of the airways and bronchiectasis. Williams–Campbell syndrome is deficiency of the bronchial cartilage distally.

Symptoms

• Persistent cough
• Wheeze
• Impaired lung function

Diagnosis

Radiologically, the lungs are overinflated and on bronchoscopy bronchomalacia is demonstrated.

History

It was described in 1960 by Howard Williams and Peter Campbell.