Ehrlichiosis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* | |||
* | ===Polymerase chain reaction (PCR)=== | ||
* | *Most effective within the acute phase of illness (first week of illness). | ||
*Negative result does not completely rule out analysis. <ref name= "CDC sym"> Centers for Disease Control and Prevention. Ehrlichiosis symptoms. http://www.cdc.gov/ehrlichiosis/symptoms/Accessed January 20,2016.</ref> | |||
===Peripheral Blood Smear=== | |||
*Most effective during the first week of illness. | |||
*May reveal morulae (microcolonies of ehrlichiae.) | |||
*Identifying the type of infected blood cell may indicate the infecting species. | |||
**E. chaffeensis infects monocytes. | |||
**E. ewingii infects granulocytes. | |||
*Verification of infecting species must be confirmed with a culture isolation at a specialized laboratory. <ref name= "CDC sym"> Centers for Disease Control and Prevention. Ehrlichiosis symptoms. http://www.cdc.gov/ehrlichiosis/symptoms/Accessed January 20,2016.</ref> | |||
===Immunofluorescence=== | |||
*Gold standard serologic test for ehrlichiosis. | |||
*Sample should be extracted as early in the disease as possible. | |||
*A second sample should be taken 2-4 weeks later. | |||
*Typically the first count is low, however will significantly increase by the second sample. | |||
*Testing should include both an IgM and IgG titer. <ref name= "CDC sym"> Centers for Disease Control and Prevention. Ehrlichiosis symptoms. http://www.cdc.gov/ehrlichiosis/symptoms/Accessed January 20,2016.</ref> | |||
==References== | ==References== | ||
Revision as of 18:38, 20 January 2016
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Laboratory Findings
Polymerase chain reaction (PCR)
- Most effective within the acute phase of illness (first week of illness).
- Negative result does not completely rule out analysis. [1]
Peripheral Blood Smear
- Most effective during the first week of illness.
- May reveal morulae (microcolonies of ehrlichiae.)
- Identifying the type of infected blood cell may indicate the infecting species.
- E. chaffeensis infects monocytes.
- E. ewingii infects granulocytes.
- Verification of infecting species must be confirmed with a culture isolation at a specialized laboratory. [1]
Immunofluorescence
- Gold standard serologic test for ehrlichiosis.
- Sample should be extracted as early in the disease as possible.
- A second sample should be taken 2-4 weeks later.
- Typically the first count is low, however will significantly increase by the second sample.
- Testing should include both an IgM and IgG titer. [1]
References
- ↑ 1.0 1.1 1.2 Centers for Disease Control and Prevention. Ehrlichiosis symptoms. http://www.cdc.gov/ehrlichiosis/symptoms/Accessed January 20,2016.