Neoplastic meningitis laboratory tests: Difference between revisions
Jump to navigation
Jump to search
| Line 6: | Line 6: | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of neoplastic meningitis include:<ref name=dxnm123>Diagnosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016</ref> | Laboratory findings consistent with the diagnosis of neoplastic meningitis include:<ref name=dxnm123>Diagnosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016</ref><ref name="AhnLim2013">{{cite journal|last1=Ahn|first1=Shin|last2=Lim|first2=Kyung Soo|title=Three Cases of Neoplastic Meningitis Initially Diagnosed with Infectious Meningitis in Emergency Department|journal=Case Reports in Emergency Medicine|volume=2013|year=2013|pages=1–4|issn=2090-648X|doi=10.1155/2013/561475}}</ref> | ||
'''CSF analysis''' | '''CSF analysis''' | ||
Revision as of 19:22, 21 January 2016
|
Neoplastic meningitis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Neoplastic meningitis laboratory tests On the Web |
|
American Roentgen Ray Society Images of Neoplastic meningitis laboratory tests |
|
Risk calculators and risk factors for Neoplastic meningitis laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory Findings
Laboratory findings consistent with the diagnosis of neoplastic meningitis include:[1][2]
CSF analysis
- Neoplastic meningitis is multifocal and cerebrospinal fluid at a particular site may show no abnormalities, if the pathological site is far away. Only 50% of those suspected with neoplastic meningitis are actually diagnosed and only the presence of malignant cells in the CSF is diagnostic.[1]
- The criteria for CSF abnormalities that are consistent with the diagnosis of neoplastic meningitis include:[1]
- Increased opening pressure (> 200mm of H2O)
- Increased Leukocytes (>4/mm3)
- Elevated protein (>50 mg/dL)
- Decreased glucose (<60 mg/dL)
- Positive tumor markers in CSF
- Carcinoembryonic antigen (CEA)
- Alpha-fetoprotein
- Beta-human chorionic gonadotropin
- Creatine-kinase BB isoenzyme
- β2 microglobulin
- Lactate dehydrogenase isoenzyme-5
- Vascular endothelial growth factor
- These markers can be good indirect indicators of n eoplastic meningitis, but most are not sensitive enough to improve cytological diagnosis.
- CSF cytology
- Malignant cells, if present, are diagnostic
- CSF cytology is estimated to have >95% specificity for neoplastic meningitis
References
- ↑ 1.0 1.1 1.2 Diagnosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016
- ↑ Ahn, Shin; Lim, Kyung Soo (2013). "Three Cases of Neoplastic Meningitis Initially Diagnosed with Infectious Meningitis in Emergency Department". Case Reports in Emergency Medicine. 2013: 1–4. doi:10.1155/2013/561475. ISSN 2090-648X.