Sandbox: ATL: Difference between revisions

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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Clinical subtype'''|| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Clinical subtype'''|| style="padding: 5px 5px; background: #F5F5F5;" |
:* Older age at the time of diagnosis is associated with a worse prognosis.
:* Acute and lymphomatous subtypes have a poor prognosis, where as chronic and smouldering subtypes have a good prognosis.
 
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Calcium level'''|| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Calcium level'''|| style="padding: 5px 5px; background: #F5F5F5;" |
:*Binet stages B and C or Rai stages 2-4 are associated with a worse prognosis.
:* Hypercalcemia is associated with a worse prognosis.


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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Leukocyte count'''|| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Leukocyte count'''|| style="padding: 5px 5px; background: #F5F5F5;" |
:*A rapid [[lymphocyte]] doubling time is associated with a worse prognosis.
:* An elevated leukocyte count is associated with a worse prognosis.
 
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Lactate dehydrogenase level'''|| style="padding: 5px 5px; background: #F5F5F5;"|
:*Deletion of [[chromosome 17]] short arm and [[chromosome 11]] long arm are associated with a worse prognosis.
 
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''β2-microglobulin level'''|| style="padding: 5px 5px; background: #F5F5F5;" |
:*An increased percentage of [[prolymphocyte]]s is associated with a worse prongnosis.
 
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Histological analysis'''|| style="padding: 5px 5px; background: #F5F5F5;"|
:*Diffuse [[histology]] on [[bone marrow aspiration]] is associated with a worse prognosis.  


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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Lactate dehydrogenase (LDH) level'''|| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Lactate dehydrogenase (LDH) level'''|| style="padding: 5px 5px; background: #F5F5F5;"|
:*Elevated level of [[LDH]] is associated with a worse prognosis.
:* Elevated level of [[LDH]] is associated with a worse prognosis.


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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''β2-microglobulin level '''|| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''β2-microglobulin level '''|| style="padding: 5px 5px; background: #F5F5F5;"|
:*Elevated level of β2-microglobulin level is associated with a worse prognosis.
:* An elevated β2-microglobulin level is associated with a worse prognosis.


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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Lymphocyte surface markers'''|| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Lymphocyte surface markers'''|| style="padding: 5px 5px; background: #F5F5F5;"|
:*Over expression of [[CD25]] is associated with a worse prognosis.
:* Over expression of [[CD25]] is associated with a worse prognosis.
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Neuron‐specific enolase'''|| style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Neuron‐specific enolase'''|| style="padding: 5px 5px; background: #F5F5F5;"|
:*The absence of IgVH [[gene]] mutation is associated with a worse prognosis.
:* An elevated neuron‐specific enolase level is associated with a worse prognosis.
 
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Membrane-bound proteins'''|| style="padding: 5px 5px; background: #F5F5F5;"|
:*The expression of zeta-chain-associated protein kinase 70 (ZAP) is associated with a worse prognosis.
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Revision as of 20:06, 24 January 2016

[1][2][3]


prognosis

high lactate dehydrogenase (LDH) high β2‐microglobulin

high serum level of CD25 high serum neuron‐specific enolase

Prognostic Factor Description
Clinical subtype
  • Acute and lymphomatous subtypes have a poor prognosis, where as chronic and smouldering subtypes have a good prognosis.
Age
  • Males are associated with a worse prognosis when compared to females.
Performance status
Calcium level
  • Hypercalcemia is associated with a worse prognosis.
Leukocyte count
  • An elevated leukocyte count is associated with a worse prognosis.
Lactate dehydrogenase (LDH) level
  • Elevated level of LDH is associated with a worse prognosis.
β2-microglobulin level
  • An elevated β2-microglobulin level is associated with a worse prognosis.
Lymphocyte surface markers
  • Over expression of CD25 is associated with a worse prognosis.
Neuron‐specific enolase
  • An elevated neuron‐specific enolase level is associated with a worse prognosis.
  1. ↑ Mahieux R, Gessain A (2007). "Adult T-cell leukemia/lymphoma and HTLV-1". Curr Hematol Malig Rep. 2 (4): 257–64. doi:10.1007/s11899-007-0035-x. PMID 20425378.
  2. ↑ Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J Clin Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.
  3. ↑ Katsuya H, Ishitsuka K, Utsunomiya A, Hanada S, Eto T, Moriuchi Y; et al. (2015). "Treatment and survival among 1594 patients with ATL". Blood. 126 (24): 2570–7. doi:10.1182/blood-2015-03-632489. PMID 26361794.
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