Neoplastic meningitis overview: Difference between revisions
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==Overview== | ==Overview== | ||
Neoplastic meningitis is the development of [[meningitis]] due to infiltration of the [[subarachnoid space]] by tumor cells. Malignant cells come from primary cancer such as [[breast cancer]] or from a primary brain tumor like [[medulloblastoma]].<ref name=overviewnm1>Neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 19, 2016</ref> | Neoplastic meningitis is the development of [[meningitis]] due to infiltration of the [[subarachnoid space]] by tumor cells. Malignant cells come from primary cancer such as [[breast cancer]] or from a primary brain tumor like [[medulloblastoma]].<ref name=overviewnm1>Neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 19, 2016</ref> The microscopic pathology of neoplastic meningitis may vary according to the primary cancer involved. Generally, on microscopic histopathological analysis, neoplastic meningitis is characterized by large, hyperchromatic cells. | ||
==Historical Perspective== | ==Historical Perspective== | ||
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==Classification== | ==Classification== | ||
There is no classification system established for neoplastic meningitis. | |||
==Pathophysiology== | ==Pathophysiology== | ||
Neoplastic meningitis refers to the spread of malignant cells through the [[cerebrospinal fluid]] space. These cells can be originated both in primary CNS tumors (e.g. drop-metastases), as well as from distant tumors that have metastasized (hematogenous spread).<ref name=nm1introduction>Leptomeningeal metastases. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningeal-metastases. Accessed on January 20, 2016</ref> The microscopic pathology of neoplastic meningitis may vary according to the primary cancer involved. Generally, on microscopic histopathological analysis, neoplastic meningitis is characterized by large, hyperchromatic cells.<ref name="BerzeroDiamanti2015">{{cite journal|last1=Berzero|first1=Giulia|last2=Diamanti|first2=Luca|last3=Di Stefano|first3=Anna Luisa|last4=Bini|first4=Paola|last5=Franciotta|first5=Diego|last6=Imarisio|first6=Ilaria|last7=Pedrazzoli|first7=Paolo|last8=Magrassi|first8=Lorenzo|last9=Morbini|first9=Patrizia|last10=Farina|first10=Lisa Maria|last11=Bastianello|first11=Stefano|last12=Ceroni|first12=Mauro|last13=Marchioni|first13=Enrico|title=Meningeal Melanomatosis: A Challenge for Timely Diagnosis|journal=BioMed Research International|volume=2015|year=2015|pages=1–6|issn=2314-6133|doi=10.1155/2015/948497}}</ref> | |||
==Causes== | ==Causes== | ||
Common causes of neoplastic meningitis include primary [[brain tumor|intracerebral malignancies]] ([[glioblastoma multiforme]], [[anaplastic astrocytoma]], [[medulloblastoma]]) and metastatic disease ([[breast cancer]], [[lung cancer]], [[melanoma]], [[lymphoma]], [[leukemia]]).<ref name=causes1>Pathology of leptomeningeal metastases. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningeal-metastases. Accessed on January 19, 2016</ref> | |||
==Differentiating Neoplastic Meningitis from other Diseases== | ==Differentiating Neoplastic Meningitis from other Diseases== | ||
Revision as of 14:26, 25 January 2016
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Neoplastic meningitis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Neoplastic meningitis overview On the Web |
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American Roentgen Ray Society Images of Neoplastic meningitis overview |
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Risk calculators and risk factors for Neoplastic meningitis overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Neoplastic meningitis is the development of meningitis due to infiltration of the subarachnoid space by tumor cells. Malignant cells come from primary cancer such as breast cancer or from a primary brain tumor like medulloblastoma.[1] The microscopic pathology of neoplastic meningitis may vary according to the primary cancer involved. Generally, on microscopic histopathological analysis, neoplastic meningitis is characterized by large, hyperchromatic cells.
Historical Perspective
Neoplastic meningitis was first reported in the 1870's.[1]
Classification
There is no classification system established for neoplastic meningitis.
Pathophysiology
Neoplastic meningitis refers to the spread of malignant cells through the cerebrospinal fluid space. These cells can be originated both in primary CNS tumors (e.g. drop-metastases), as well as from distant tumors that have metastasized (hematogenous spread).[2] The microscopic pathology of neoplastic meningitis may vary according to the primary cancer involved. Generally, on microscopic histopathological analysis, neoplastic meningitis is characterized by large, hyperchromatic cells.[3]
Causes
Common causes of neoplastic meningitis include primary intracerebral malignancies (glioblastoma multiforme, anaplastic astrocytoma, medulloblastoma) and metastatic disease (breast cancer, lung cancer, melanoma, lymphoma, leukemia).[4]
Differentiating Neoplastic Meningitis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
There are no primary or secondary preventive measures available for neoplastic meningitis.
References
- ↑ 1.0 1.1 Neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 19, 2016
- ↑ Leptomeningeal metastases. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningeal-metastases. Accessed on January 20, 2016
- ↑ Berzero, Giulia; Diamanti, Luca; Di Stefano, Anna Luisa; Bini, Paola; Franciotta, Diego; Imarisio, Ilaria; Pedrazzoli, Paolo; Magrassi, Lorenzo; Morbini, Patrizia; Farina, Lisa Maria; Bastianello, Stefano; Ceroni, Mauro; Marchioni, Enrico (2015). "Meningeal Melanomatosis: A Challenge for Timely Diagnosis". BioMed Research International. 2015: 1–6. doi:10.1155/2015/948497. ISSN 2314-6133.
- ↑ Pathology of leptomeningeal metastases. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningeal-metastases. Accessed on January 19, 2016