Sandbox: differentialdx maria: Difference between revisions
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!style="background: #4479BA; width: 300px;" |{{fontcolor|#FFF|Genes implicated in HNPCC}} | |||
!style="background: #4479BA; width: 300px;" |{{fontcolor|#FFF|Frequency of mutations in HNPCC families}} | |||
!style="background: #4479BA; width: 300px;" |{{fontcolor|#FFF|Locus}} | |||
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[MSH2]] | |||
|style="padding: 5px 5px; background: #F5F5F5;"|approximately 60% | |||
|style="padding: 5px 5px; background: #F5F5F5;"|2p22 | |||
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[MLH1]] | |||
|style="padding: 5px 5px; background: #F5F5F5;"| approximately 30% | |||
|style="padding: 5px 5px; background: #F5F5F5;"|3p21 | |||
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[MSH6]] | |||
|style="padding: 5px 5px; background: #F5F5F5;"| 7-10% | |||
|style="padding: 5px 5px; background: #F5F5F5;"|2p16 | |||
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[PMS2]] | |||
|style="padding: 5px 5px; background: #F5F5F5;"|relatively infrequent | |||
|style="padding: 5px 5px; background: #F5F5F5;"|7p22 | |||
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[PMS1]] | |||
|style="padding: 5px 5px; background: #F5F5F5;"|case report | |||
|style="padding: 5px 5px; background: #F5F5F5;"|2q31-q33 | |||
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[TGFBR2]] | |||
|style="padding: 5px 5px; background: #F5F5F5;"|case report | |||
|style="padding: 5px 5px; background: #F5F5F5;"|3p22 | |||
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[MLH3]] | |||
|style="padding: 5px 5px; background: #F5F5F5;"|disputed | |||
|style="padding: 5px 5px; background: #F5F5F5;"|14q24.3 | |||
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Revision as of 16:14, 25 January 2016
Genes implicated in HNPCC | Frequency of mutations in HNPCC families | Locus |
---|---|---|
MSH2 | approximately 60% | 2p22 |
MLH1 | approximately 30% | 3p21 |
MSH6 | 7-10% | 2p16 |
PMS2 | relatively infrequent | 7p22 |
PMS1 | case report | 2q31-q33 |
TGFBR2 | case report | 3p22 |
MLH3 | disputed | 14q24.3 |
Type of osteoid osteoma | Characteristics |
---|---|
Intracortical | Dense sclerosis around the nidus |
Periosteal | Periosteal reaction |
Cancellous (medullary) | Produces very little reactive bone |
Subarticular | Simulates arthritis as it produces synovial reactions |
Differential Diagnosis | Similar Features | Differentiating Features |
---|---|---|
Osteoblastoma |
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Brodie abscess |
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Osteosarcoma |
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Enostosis |
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Differential Diagnosis | Similar Features | Differentiating Features |
---|---|---|
Fibrous dysplasia |
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Osteoblastoma |
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Adamantinomas |
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Chronic sinusitis |
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Differential Diagnosis | Similar Features | Differentiating Features |
---|---|---|
Cardiac tamponade |
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Chronic obstructive pulmonary disease |
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Mediastinitis |
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Pneumonia |
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Acute respiratory distress syndrome |
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Syphilis |
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Differential Diagnosis | Similar Features | Differentiating Features |
---|---|---|
Familial adenomatous polyposis (FAP) |
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Juvenile polyposis |
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Cowden syndrome |
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