Fibroadenoma pathophysiology: Difference between revisions
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==Pathogenesis== | ==Pathogenesis== | ||
* Fibroadenoma arises from connective tissue cells, which are cells that are normally involved in the functional and mechanical support of the surrounding organs parenchymal cells. | * Fibroadenoma arises from connective tissue cells, which are cells that are normally involved in the functional and mechanical support of the surrounding organs parenchymal cells. | ||
* Fibroadenomas characteristically contain both stromal and epithelial cells. | |||
* Fibroadenoma tumor cells are typically positive for estrogen receptors, which leads to the hormonal sensitivity of the tumor. | |||
* It is thought that the hormone-receptor mechanism mediates the excessive proliferation of epithelial and stromal cells.<ref name="pmid16554735">{{cite journal| author=Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G et al.| title=Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. | journal=Mod Pathol | year= 2006 | volume= 19 | issue= 4 | pages= 599-606 | pmid=16554735 | doi=10.1038/modpathol.3800574 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16554735 }} </ref> | |||
* | |||
==Genetics== | ==Genetics== | ||
==Associated Conditions== | ==Associated Conditions== | ||
Revision as of 16:28, 28 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
- Fibroadenoma arises from connective tissue cells, which are cells that are normally involved in the functional and mechanical support of the surrounding organs parenchymal cells.
- Fibroadenomas characteristically contain both stromal and epithelial cells.
- Fibroadenoma tumor cells are typically positive for estrogen receptors, which leads to the hormonal sensitivity of the tumor.
- It is thought that the hormone-receptor mechanism mediates the excessive proliferation of epithelial and stromal cells.[1]
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
References
- ↑ Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G; et al. (2006). "Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast". Mod Pathol. 19 (4): 599–606. doi:10.1038/modpathol.3800574. PMID 16554735.