Fibroadenoma pathophysiology: Difference between revisions
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* Fibroadenoma arises from connective tissue cells, which are cells that are normally involved in the functional and mechanical support of the surrounding tissues. | * Fibroadenoma arises from connective tissue cells, which are cells that are normally involved in the functional and mechanical support of the surrounding tissues. | ||
* The majority of fibroadenomas are benign and do not demonstrate any malignant potential. | * The majority of fibroadenomas are benign and do not demonstrate any malignant potential. | ||
* Fibroadenomas characteristically contain both stromal and epithelial cells. | * Fibroadenomas characteristically contain both stromal and epithelial connective tissue cells. | ||
* Fibroadenoma demonstrate estrogen and progesterone sensitivity and may grow during pregnancy. | * Fibroadenoma demonstrate estrogen and progesterone sensitivity and may grow during pregnancy. | ||
* It is thought that the hormone-receptor mechanism mediates the excessive proliferation of epithelial and stromal cells.<ref name="pmid16554735">{{cite journal| author=Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G et al.| title=Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. | journal=Mod Pathol | year= 2006 | volume= 19 | issue= 4 | pages= 599-606 | pmid=16554735 | doi=10.1038/modpathol.3800574 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16554735 }} </ref> | * It is thought that the hormone-receptor mechanism mediates the excessive proliferation of epithelial and stromal cells.<ref name="pmid16554735">{{cite journal| author=Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G et al.| title=Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. | journal=Mod Pathol | year= 2006 | volume= 19 | issue= 4 | pages= 599-606 | pmid=16554735 | doi=10.1038/modpathol.3800574 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16554735 }} </ref> | ||
Revision as of 16:41, 28 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
- Fibroadenoma arises from connective tissue cells, which are cells that are normally involved in the functional and mechanical support of the surrounding tissues.
- The majority of fibroadenomas are benign and do not demonstrate any malignant potential.
- Fibroadenomas characteristically contain both stromal and epithelial connective tissue cells.
- Fibroadenoma demonstrate estrogen and progesterone sensitivity and may grow during pregnancy.
- It is thought that the hormone-receptor mechanism mediates the excessive proliferation of epithelial and stromal cells.[1]
- Although fibroadenomas may be develop in any part of the breast, there is a significant predilection for the upper outer quadrant.
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
References
- ↑ Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G; et al. (2006). "Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast". Mod Pathol. 19 (4): 599–606. doi:10.1038/modpathol.3800574. PMID 16554735.