Fibroadenoma pathophysiology: Difference between revisions
Jump to navigation
Jump to search
| Line 34: | Line 34: | ||
:* Hypovascular stroma | :* Hypovascular stroma | ||
:* The epithelial proliferation appears in a single terminal ductal unit | :* The epithelial proliferation appears in a single terminal ductal unit | ||
==Gallery== | |||
<gallery> | <gallery> | ||
Image: | Image: | ||
Fibroadenoma 1.jpg | |||
</gallery> | </gallery> | ||
Revision as of 13:24, 29 January 2016
|
Fibroadenoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Fibroadenoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of Fibroadenoma pathophysiology |
|
Risk calculators and risk factors for Fibroadenoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
- Fibroadenoma is a common benign tumor of the breast.
- Fibroadenoma arises from connective tissue cells, which are cells that are normally involved in the functional and mechanical support of the surrounding tissues.
- The majority of fibroadenomas are benign and do not demonstrate any malignant potential.
- Fibroadenomas typically contain both stromal and epithelial connective tissue cells.
- Fibroadenoma demonstrate estrogen and progesterone sensitivity and may grow during pregnancy.
- It is thought that the hormone-receptor mechanism mediates the excessive proliferation of epithelial and stromal cells.[1]
- Although fibroadenomas may be develop in any part of the breast, there is a significant predilection for the upper outer quadrant.
Genetics
Associated Conditions
Gross Pathology
- On gross pathology, a painless, firm, solitary, mobile, and slowly growing breast lump is a characteristic finding of fibroadenoma.
- Other charectersitic findings on gross examination of fibroadenoma include:
- Rubbery texture
- Tan/white colored
- Lobulated appearance
- Short slit-like spaces present
- Calcifications
Microscopic Pathology
- On microscopic pathology, charectersitic findings of fibroadenoma include:
- Biphasic proliferation of both stromal and epithelial components that can be arranged in two growth patterns:
- Pericanalicular growth pattern: stromal proliferation around epithelial structures
- Intracanalicular growth pattern: stromal proliferation compressing the epithelial structures into clefts
- Hypovascular stroma
- The epithelial proliferation appears in a single terminal ductal unit
Gallery
References
- ↑ Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G; et al. (2006). "Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast". Mod Pathol. 19 (4): 599–606. doi:10.1038/modpathol.3800574. PMID 16554735.