Trichinosis natural history, complications, and prognosis: Difference between revisions

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==Overview==
==Overview==
If left untreated, patients with trichinosis may progress to develop periorbital edema, muscle pain, and fever.<ref name="wiki1234">Trichinosis. Wikipedia. https://en.wikipedia.org/wiki/Trichinosis. Accessed on January 22, 2016</ref><ref name="pmid19136437">{{cite journal| author=Gottstein B, Pozio E, Nöckler K| title=Epidemiology, diagnosis, treatment, and control of trichinellosis. | journal=Clin Microbiol Rev | year= 2009 | volume= 22 | issue= 1 | pages= 127-45, Table of Contents | pmid=19136437 | doi=10.1128/CMR.00026-08 | pmc=PMC2620635 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19136437  }} </ref> Common complications of trichinosis affect cardiovascular, neurological, ocular, respiratory and digestive systems.<ref name=abc>FAO/WHO/OIE Guidelines for the surveillance, management, prevention and control of trichinellosis. FAO (2007). http://www.fao.org/documents/card/en/c/61e00fb1-87e8-5b89-8be1-50481e43eed1/ Accessed on January 28, 2016 </ref> Most people with trichinosis have no symptoms, the infection goes away by itself. The prognosis of trichinosis is good with treatment.<ref name=bb>Trichinosis. MedlinePlus. https://www.nlm.nih.gov/medlineplus/ency/article/000631.htm Accessed on January 28, 2016  </ref>The most dangerous case is worms entering the [[central nervous system]]. They cannot survive there, but they may cause enough damage to produce serious neurological deficits (such as [[ataxia]] or respiratory paralysis), and even [[death]]. Infestation of the [[heart]] may also lead to death.<ref name="wiki1234">Trichinosis. Wikipedia. https://en.wikipedia.org/wiki/Trichinosis. Accessed on January 22, 2016</ref>
If left untreated, patients with trichinosis may progress to develop [[periorbital edema]], [[muscle pain]], and [[fever]].<ref name="wiki1234">Trichinosis. Wikipedia. https://en.wikipedia.org/wiki/Trichinosis. Accessed on January 22, 2016</ref><ref name="pmid19136437">{{cite journal| author=Gottstein B, Pozio E, Nöckler K| title=Epidemiology, diagnosis, treatment, and control of trichinellosis. | journal=Clin Microbiol Rev | year= 2009 | volume= 22 | issue= 1 | pages= 127-45, Table of Contents | pmid=19136437 | doi=10.1128/CMR.00026-08 | pmc=PMC2620635 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19136437  }} </ref> [[Complications]] of trichinosis affect the [[cardiovascular]], [[neurological]], [[ocular]], [[respiratory]] and [[Digestive system|digestive systems]].<ref name="abc">FAO/WHO/OIE Guidelines for the surveillance, management, prevention and control of trichinellosis. FAO (2007). http://www.fao.org/documents/card/en/c/61e00fb1-87e8-5b89-8be1-50481e43eed1/ Accessed on January 28, 2016 </ref> Most people with trichinosis have no [[symptoms]], the [[infection]] goes away by itself. The [[prognosis]] of trichinosis is good with treatment.<ref name="bb">Trichinosis. MedlinePlus. https://www.nlm.nih.gov/medlineplus/ency/article/000631.htm Accessed on January 28, 2016  </ref> The most dangerous case is worms entering the [[central nervous system]]. They cannot survive there, but they may cause enough damage to produce serious [[Neurological disorders|neurological deficits]] (such as [[ataxia]] or respiratory paralysis), and even death. Infestation of the [[heart]] may also lead to death.<ref name="wiki1234">Trichinosis. Wikipedia. https://en.wikipedia.org/wiki/Trichinosis. Accessed on January 22, 2016</ref>
===Natural History===
===Natural History===
*The symptoms vary depending on the phase, species of Trichinella, amount of encysted larvae ingested, age, gender, and host immunity.
*The [[symptoms]] vary depending on the phase, species of [[Trichinella]], amount of encysted larvae ingested, [[age]], gender, and host immunity.
*Patients infected by 10 or less larvae have either minor or no symptoms and no complications.
*Patients infected by 10 or less larvae have either minor or no [[symptoms]] and no [[complications]].
*Enteral/Intestinal phase:  
*Enteral/Intestinal phase:  
**From two to seven days after infection.
**From two to seven days after [[infection]].
**The large burden of adult worms in the intestines promote symptoms such as nausea, heartburn, dyspepsia, and diarrhea.
**The large burden of adult worms in the [[intestines]] promote [[symptoms]] such as [[nausea]], [[heartburn]], [[dyspepsia]], and [[diarrhea]].
*Parenteral/muscle phase:
*Parenteral/muscle phase:
**Seven days after infection.
**Seven days after [[infection]].
**The severity of symptoms caused by larval migration from the intestines depends on the number of larvae produced.  
**The severity of [[symptoms]] caused by larval migration from the [[intestines]] depends on the number of larvae produced.  
**As the larvae migrate through tissue and vessels, the body's inflammatory response results in: edema, muscle pain, fever, and weakness.  
**As the larvae migrate through [[tissue]] and [[vessels]], the body's inflammatory response results in: [[edema]], [[muscle pain]], [[fever]], and [[Weakness (medical)|weakness]].  
**A classic sign of trichinosis is periorbital edema, swelling around the eyes, which may be caused by vasculitis.  
**A classic sign of trichinosis is [[periorbital edema]], [[Periorbital edema|swelling around the eyes]], which may be caused by [[vasculitis]].  
**Splinter hemorrhage in the nails is also a common symptom.
**[[Splinter hemorrhage]] in the nails is also a common symptom.
**If left untreated, the worms may cause enough damage to produce serious neurological deficits (such as ataxia or respiratory paralysis) from worms entering the central nervous system.  
**If left untreated, the worms may cause enough damage to produce serious [[Neurological disorders|neurological deficits]] (such as [[ataxia]] or respiratory paralysis) from worms entering the [[central nervous system]] (CNS).  
**The CNS is compromised by trichinosis in 10–24% of reported cases of cerebral venous sinus thrombosis, a very rare form of stroke (3-4 cases per million annual incidence in adults).
**The [[CNS]] is compromised by trichinosis in 10–24% of reported cases of [[cerebral venous sinus thrombosis]], a very rare form of [[stroke]] (3-4 cases per million annual incidence in adults).
**Trichinosis can be fatal depending on the severity of the infection; death can occur 4–6 weeks after the infection, and is usually caused by myocarditis, encephalitis, or pneumonia.<ref name="wiki1234">Trichinosis. Wikipedia. https://en.wikipedia.org/wiki/Trichinosis. Accessed on January 22, 2016</ref><ref name="pmid19136437">{{cite journal| author=Gottstein B, Pozio E, Nöckler K| title=Epidemiology, diagnosis, treatment, and control of trichinellosis. | journal=Clin Microbiol Rev | year= 2009 | volume= 22 | issue= 1 | pages= 127-45, Table of Contents | pmid=19136437 | doi=10.1128/CMR.00026-08 | pmc=PMC2620635 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19136437  }} </ref>
**Trichinosis can be fatal depending on the severity of the [[infection]]; death can occur 4–6 weeks after the [[infection]], and is usually caused by [[myocarditis]], [[encephalitis]], or [[pneumonia]].<ref name="wiki1234">Trichinosis. Wikipedia. https://en.wikipedia.org/wiki/Trichinosis. Accessed on January 22, 2016</ref><ref name="pmid19136437">{{cite journal| author=Gottstein B, Pozio E, Nöckler K| title=Epidemiology, diagnosis, treatment, and control of trichinellosis. | journal=Clin Microbiol Rev | year= 2009 | volume= 22 | issue= 1 | pages= 127-45, Table of Contents | pmid=19136437 | doi=10.1128/CMR.00026-08 | pmc=PMC2620635 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19136437  }} </ref>
===Complications===
===Complications===
Common complications of trichinosis include:
Common [[complications]] of trichinosis include:
*Cardiovascular:
*[[Cardiovascular]]:
** [[Heart failure]]
** [[Heart failure]]
** Heart rhythm problems ([[arrhythmias]]) from heart inflammation ([[myocarditis]])
** [[Heart rhythm]] problems ([[arrhythmias]]) from heart inflammation ([[myocarditis]])
**Thromboembolic disease
**[[Thromboembolic disease]]
*** Deep thrombophlebitis
*** [[Deep thrombophlebitis]]
***Intraventricular thrombi
***Intraventricular thrombi
***Pulmonary embolism
***[[Pulmonary embolism]]
**Paroxysmal tachycardia
**[[Paroxysmal tachycardia]]
**Pericardial effusion
**[[Pericardial effusion]]
*Neurological:
*[[Neurological|Neurological:]]
**Encephalophalitis
**[[Encephalomyelitis]]
**Neuromuscular disturbances:
**[[Neuromuscular disorder|Neuromuscular disturbances]]:
***Decreased muscular strength and tendon reflexes
***Decreased [[muscular strength]] and [[Tendon reflex|tendon reflexes]]
***Dysphagia
***[[Dysphagia]]
***Trismus
***[[Trismus]]
*Ocular:
*[[Ocular]]:
**Edema and vascular lesions within the conjunctiva, uvea, retina, and, in some cases, the optic nerve
**[[Edema]] and [[Vascular anomaly|vascular lesions]] within the [[conjunctiva]], [[uvea]], [[retina]], and, in some cases, the [[optic nerve]]
**Pain when moving the eyeballs
**Pain when moving the eyeballs
**Muscle paralysis
**[[Muscle]] paralysis
**Diplopia
**[[Diplopia]]
**Disturbed accommodation
**Disturbed [[Accommodation (eye)|accommodation]]
*Respiratory:
*[[Respiratory]]:
**Dyspnea
**[[Dyspnea]]
**Pneumonia
**[[Pneumonia]]
**obstructive bronchitis
**Obstructive [[bronchitis]]
**Löffler-type infiltrates or ventilature failures
**Löffler-type infiltrates or ventilature failures
*Digestive:
*[[Digestive]]:
**Hypoalbuminemia
**[[Hypoalbuminemia]]
**Acute intestinal necrosis  
**Acute [[intestinal]] [[necrosis]]
**Prolonged diarrhoea<ref name=abc>FAO/WHO/OIE Guidelines for the surveillance, management, prevention and control of trichinellosis. FAO (2007). http://www.fao.org/documents/card/en/c/61e00fb1-87e8-5b89-8be1-50481e43eed1/ Accessed on January 28, 2016  </ref>
**Prolonged [[diarrhoea]]<ref name="abc">FAO/WHO/OIE Guidelines for the surveillance, management, prevention and control of trichinellosis. FAO (2007). http://www.fao.org/documents/card/en/c/61e00fb1-87e8-5b89-8be1-50481e43eed1/ Accessed on January 28, 2016  </ref>


===Prognosis===
===Prognosis===
*Most people with trichinosis have no symptoms and the infection goes away by itself. More severe infections may be more difficult to treat, especially if the lungs, the heart, or the brain is involved.<ref name=bb>Trichinosis. MedlinePlus. https://www.nlm.nih.gov/medlineplus/ency/article/000631.htm Accessed on January 28, 2016  </ref>
*Most people with trichinosis have no [[symptoms]] and the [[infection]] goes away by itself. More severe [[infections]] may be more difficult to treat, especially if the [[lungs]], the [[heart]], or the [[brain]] is involved.<ref name="bb">Trichinosis. MedlinePlus. https://www.nlm.nih.gov/medlineplus/ency/article/000631.htm Accessed on January 28, 2016  </ref>


==References==
==References==
{{reflist|2}}
{{reflist|2}}


[[Category:Conditions diagnosed by stool test]]
[[Category:Conditions diagnosed by stool test]]

Revision as of 21:28, 29 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Danitza Lukac

Overview

If left untreated, patients with trichinosis may progress to develop periorbital edema, muscle pain, and fever.[1][2] Complications of trichinosis affect the cardiovascular, neurological, ocular, respiratory and digestive systems.[3] Most people with trichinosis have no symptoms, the infection goes away by itself. The prognosis of trichinosis is good with treatment.[4] The most dangerous case is worms entering the central nervous system. They cannot survive there, but they may cause enough damage to produce serious neurological deficits (such as ataxia or respiratory paralysis), and even death. Infestation of the heart may also lead to death.[1]

Natural History

Complications

Common complications of trichinosis include:

Prognosis

References

  1. ↑ 1.0 1.1 1.2 Trichinosis. Wikipedia. https://en.wikipedia.org/wiki/Trichinosis. Accessed on January 22, 2016
  2. ↑ 2.0 2.1 Gottstein B, Pozio E, Nöckler K (2009). "Epidemiology, diagnosis, treatment, and control of trichinellosis". Clin Microbiol Rev. 22 (1): 127–45, Table of Contents. doi:10.1128/CMR.00026-08. PMC 2620635. PMID 19136437.
  3. ↑ 3.0 3.1 FAO/WHO/OIE Guidelines for the surveillance, management, prevention and control of trichinellosis. FAO (2007). http://www.fao.org/documents/card/en/c/61e00fb1-87e8-5b89-8be1-50481e43eed1/ Accessed on January 28, 2016
  4. ↑ 4.0 4.1 Trichinosis. MedlinePlus. https://www.nlm.nih.gov/medlineplus/ency/article/000631.htm Accessed on January 28, 2016

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