Histoplasmosis pathophysiology: Difference between revisions

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Revision as of 15:41, 1 February 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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 ==Pathophysiology==
-===H.Capsulatum===
-''H. capsulatum'' is found throughout the world and is [[Endemic (epidemiology)|endemic]] in certain areas of the United States, particularly in states bordering the Ohio River valley and the lower Mississippi River. (Positive histoplasmin skin tests occur in as many as 80% of the people living in areas where H. capsulatum is common, such as the eastern and central United States.) H. capsulatum grows in soil and material contaminated with bat or bird droppings. The fungus has been found in poultry house litter, caves, areas harboring bats, and in bird roosts (particularly those of starlings). The fungus is thermally dimorphic. In the environment it grows as a brownish [[mycelium]], whereas at body temperature (37°C in humans) it morphs into a [[yeast]]. The inoculum is represented principally by microconidia that, once inhaled into the [[Pulmonary alveolus|alveolar]] spaces, germinate and then transform into budding yeast cells.
 ==References==