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===Other Imaging Findings===
===Other Imaging Findings===


Other imaging findings, include nuclear medicine (bone scintigraphy) in which osteochondroma shows increased uptake on bone scans. Conversely, presence of increased activity in adults should raise the possibility of a complication (e.g. fracture, malignancy).<ref name= "radio"> Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016</ref>
Other imaging findings, include nuclear medicine (bone [[scintigraphy]]) in which osteochondroma shows increased uptake on bone scans. Conversely, presence of increased activity in adults should raise the possibility of a complication (e.g. [[fracture]], [[malignancy]]).<ref name= "radio"> Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016</ref>


===Other Diagnostic Studies===
===Other Diagnostic Studies===

Revision as of 21:30, 1 February 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Osteochondroma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Osteochondroma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Overview

Osteochondroma (also known as "osteocartilaginous exostosis") is a benign bone tumor that consists of cartilage and bone. Osteochondromas arise from cartilage, which is normally involved in the mechanical support of the bone. These tumors take the form of cartilage-capped bony projections or outgrowth on the surface of bones, also known as exostoses.[1] Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones. Osteochondromas may be classified into 2 subtypes: solitary osteochondromas (non-hereditary) and multiple osteochondromas (hereditary); the majority of these tumors present as solitary lesions (85%).[2] Development of osteochondromas is the result of the developmental anomaly of skeletal growth. Genes involved in the pathogenesis of osteochondroma include EXT1 and EXT2 genes. Osteochondroma is associated with a number of syndromes that include Langer-Giedion syndrome, Potocki-Shaffer syndrome, and metachondromatosis syndrome. Osteochondromas are usually found in adolescents and children. Males are more commonly affected with osteochondroma than females. The incidence of osteochondroma is approximately 0.9 per 100,000 individuals. If left untreated, progression occurs slow and is then followed by malignant transformation. The treatment choice for osteochondroma is surgical removal of solitary lesion or partial excision of the outgrowth.

Historical Perspective

Osteochondroma was first described by Henry L. Jaffe, an American pathologist, in 1952.[3]

Classification

Osteochondromas may be classified into 2 subtypes: solitary osteochondromas (non-hereditary) and multiple osteochondromas (hereditary).[2]

Pathophysiology

Osteochondroma arises from the cartilage cells (chondrocytes), which are normally involved in the mechanical support of the bone. The pathogenesis of osteochondroma consists of abnormal outgrowth of bone and cartilage, associated with the aberrant development of the growth plate.[2] Genes involved in the pathogenesis of osteochondroma include EXT1 and EXT2 genes. Osteochondroma is associated with a number of syndromes that include Langer-Giedion syndrome, Potocki-Shaffer syndrome, and metachondromatosis syndrome. On gross pathology, osteochondromas have a "mushroom-like shape", the tumor size ranges from 1 to 2 cm, and they are normally located on the metaphysial region of the affected bone.[4] On microscopic histopathological analysis, osteochondroma shows cartilage cells growing in columns with a lobular arrangement.[5]

Causes

There are no established direct causes for osteochondroma. The development of hereditary multiple osteochondroma may be the result of multiple genetic mutations.[2]

Differentiating Osteoid Osteoma from other Diseases

Osteochondroma must be differentiated from other diseases that cause bone deformity, bone growth, overlying bursitis, and mechanical joint problems such as enchondroma, chondroblastoma, periosteal chondroma, and chondromyxoid fibroma.[2]

Epidemiology and Demographics

Osteochondroma is the most common benign bone tumor among general population.[6] The incidence of osteochondroma is approximately 0.9 per 100,000 individuals in the general population. The incidence of osteochondroma decreases with age; the median age at diagnosis is between 10 to 13 years. Males are more commonly affected with osteochondroma than females. Osteochondroma usually affects individuals of the Caucasian race.[2]

Risk Factors

Common risk factors in the development of osteochondromas, include: previous trauma to the growth plate, exposure to previous radiation, and congenital limb anomalies.[6]

Screening

According to the the Canadian Society of Cancer, there is insufficient evidence to recommend routine screening for osteochondroma.[7]

Natural History, Complications and Prognosis

If left untreated, patients with osteochondroma may progress to develop overlying bursitis, vascular compromise, and rise to malignant chondrosarcoma. Common complications of osteochondroma include fracture, osseous deformation, and growth arrest. Prognosis is generally regarded as good after surgical excision. The recurrence rate of osteochondroma is 2%.[6]

Diagnosis

Staging

According to the Musculoskeletal Tumor Society (MSTS) classification, there are 3 stages of osteochondroma based on the tumoral activity. Each stage is assigned a number that designate the level of bone erosion. The different stages of osteochondroma, include: stage I, stage II, and stage III.[8]

History and Symptoms

The hallmark of osteochondroma is a painless growing mass. A positive history of Langer-Giedion syndrome, Potocki-Shaffer syndrome, or metachondromatosis syndrome is highly suggestive of multiple osteochondromas. Symptoms related with osteochondroma will vary depending on the size and location of the tumor. Common symptoms of osteochondroma may include limb numbness, adjacent muscle soreness, and claudication.[2]

Physical Examination

Physical examination findings of osteochondroma will depend on the location of the tumor. Physical examination of patients with osteochondroma is usually remarkable for bone deformity, limited range of limb motion, loss of pulse, and color change.[2]

Laboratory Findings

There are no diagnostic laboratory findings associated with osteochondroma.

X Ray

On conventional radiography, characteristic osteochondroma findings, include: sessile or pedunculated bony growth, metaphyseal region location, bone growth projecting away from the epiphysis, and broadening of the metaphysis.[9]

CT

On CT scan, osteochondroma shows the same findings as on radiograph, but it has better accuracy to demonstrate medullary continuity and the cartilage cap.[9]

MRI

On MRI, osteochondroma shows cartilage thickness (and thus assessing for malignant transformation), presence of edema in bone or adjacent soft tissues, and visualization of neurovascular structures. MRI is the imaging modality of choice to assess malignant transformation of osteochondroma.[9]

Ultrasound

On ultrasound, the osteochondroma cartilage cap is visualized accurately as a hypoechoic region bounded by bone.[9]

Other Imaging Findings

Other imaging findings, include nuclear medicine (bone scintigraphy) in which osteochondroma shows increased uptake on bone scans. Conversely, presence of increased activity in adults should raise the possibility of a complication (e.g. fracture, malignancy).[9]

Other Diagnostic Studies

There are no other diagnostic studies for osteochondroma.[9]

Treatment

Medical Therapy

There is no treatment for osteochondroma; Observation surveillance is suggested if lesions are asymptomatic.

Surgery

Surgery is the mainstay of therapy for osteochondroma. Surgery for osteochondroma should be considered, until bone growth is complete (assessed by mature skeleton x-ray evaluation).[10]

Primary Prevention

There is no primary prevention for osteochondroma.

Secondary Prevention

There is no secondary prevention for osteochondroma.

References

  1. Panagiotis, Kitsoulis; Vassiliki Galani; Kalliopi Stefanaki; Georgios Paraskevas; Georgios Karatzias; Niki John Agnantis; Maria Bai (October 2008). "Osteochondromas: Review of the Clinical, Radiological and Pathological Features". In Vivo. 22 (5): 633–646. Retrieved 22 March 2014.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M (2008). "Osteochondromas: review of the clinical, radiological and pathological features". In Vivo (Athens, Greece). 22 (5): 633–46. PMID 18853760.
  3. Tumors and Tumorous Conditions of the Bones and Joints by Henry L. Jaffe, Philadelphia, Lea and Febiger 1958
  4. Osteochondroma. Libre Pathology. http://librepathology.org/wiki/index.php/Osteochondroma Accessed on January 27, 2015
  5. Porter DE, Simpson AH (1999). <119::AID-PATH321>3.0.CO;2-N "The neoplastic pathogenesis of solitary and multiple osteochondromas". The Journal of Pathology. 188 (2): 119–25. doi:10.1002/(SICI)1096-9896(199906)188:2<119::AID-PATH321>3.0.CO;2-N. PMID 10398153.
  6. 6.0 6.1 6.2 Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH (2000). "Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation". Radiographics : a Review Publication of the Radiological Society of North America, Inc. 20 (5): 1407–34. doi:10.1148/radiographics.20.5.g00se171407. PMID 10992031.
  7. Osteochondroma. Candian Society of Cancer. http://www.cancer.ca/en/cancer-information/cancer-type/bone/bone-cancer/benign-tumours/?region=bc Accessed on January 27, 2016
  8. Jawad MU, Scully SP (2010). "In brief: classifications in brief: enneking classification: benign and malignant tumors of the musculoskeletal system". Clinical Orthopaedics and Related Research. 468 (7): 2000–2. doi:10.1007/s11999-010-1315-7. PMC 2882012. PMID 20333492.
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016
  10. Diagnostic Radiology: Musculoskeletal Imaging: Osteochondroma. WikiBooks.(2015)https://en.wikibooks.org/wiki/Diagnostic_Radiology/Musculoskeletal_Imaging/Tumors_Basic/Osteochondroma Accessed on January 28, 2016

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