Brucellosis diagnostic criteria: Difference between revisions
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==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
*Clinical Description | *'''Clinical Description''' | ||
**An illness characterized by acute or insidious onset of fever and one or more of the following: | **An illness characterized by acute or insidious onset of fever and one or more of the following: | ||
***Night sweats | ***Night sweats | ||
| Line 19: | Line 19: | ||
***Meningitis | ***Meningitis | ||
***Focal organ involvement (endocarditis, orchitis/epididymitis, hepatomegaly, splenomegaly) | ***Focal organ involvement (endocarditis, orchitis/epididymitis, hepatomegaly, splenomegaly) | ||
*Laboratory Criteria for Diagnosis | *'''Laboratory Criteria for Diagnosis''' | ||
**Definitive: | **''Definitive:'' | ||
***Culture and identification of Brucella spp. from clinical specimens | ***Culture and identification of Brucella spp. from clinical specimens | ||
***Evidence of a fourfold or greater rise in Brucella antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart | ***Evidence of a fourfold or greater rise in Brucella antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart | ||
**Presumptive: | **''Presumptive:'' | ||
***Brucella total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or Brucella microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms | ***Brucella total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or Brucella microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms | ||
***Detection of Brucella DNA in a clinical specimen by PCR assay | ***Detection of Brucella DNA in a clinical specimen by PCR assay | ||
Case Classification | '''Case Classification''' | ||
*Probable | *''Probable'' | ||
**A clinically compatible illness with at least one of the following: | **A clinically compatible illness with at least one of the following: | ||
***Epidemiologically linked to a confirmed human or animal brucellosis case | ***Epidemiologically linked to a confirmed human or animal brucellosis case | ||
***Presumptive laboratory evidence, but without definitive laboratory evidence, of Brucella infection | ***Presumptive laboratory evidence, but without definitive laboratory evidence, of Brucella infection | ||
*Confirmed | *''Confirmed'' | ||
**A clinically compatible illness with definitive laboratory evidence of Brucella infection<ref name="e">Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016</ref> | **A clinically compatible illness with definitive laboratory evidence of Brucella infection<ref name="e">Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016</ref> | ||
Revision as of 21:48, 2 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Danitza Lukac
Overview
The diagnosis of brucellosis is based on the clinical and laboratory criteria.[1]
Diagnostic Criteria
- Clinical Description
- An illness characterized by acute or insidious onset of fever and one or more of the following:
- Night sweats
- Arthralgia
- Headache
- Fatigue
- Anorexia
- Myalgia
- Weight loss
- Arthritis/spondylitis
- Meningitis
- Focal organ involvement (endocarditis, orchitis/epididymitis, hepatomegaly, splenomegaly)
- An illness characterized by acute or insidious onset of fever and one or more of the following:
- Laboratory Criteria for Diagnosis
- Definitive:
- Culture and identification of Brucella spp. from clinical specimens
- Evidence of a fourfold or greater rise in Brucella antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart
- Presumptive:
- Brucella total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or Brucella microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms
- Detection of Brucella DNA in a clinical specimen by PCR assay
- Definitive:
Case Classification
- Probable
- A clinically compatible illness with at least one of the following:
- Epidemiologically linked to a confirmed human or animal brucellosis case
- Presumptive laboratory evidence, but without definitive laboratory evidence, of Brucella infection
- A clinically compatible illness with at least one of the following:
- Confirmed
- A clinically compatible illness with definitive laboratory evidence of Brucella infection[1]
Reference
- ↑ 1.0 1.1 Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016