Langerhans cell histiocytosis classification: Difference between revisions
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==Overview== | ==Overview== | ||
==Classification== | ==Classification== | ||
* Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis. | |||
* The table below lists the features of each specific Langerhans cell histiocytosis subtype: | |||
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! style="background: #4479BA; width: 650px; color: #FFFFFF;"|'''Subtype''' | |||
! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Organ Involvement''' | |||
! style="background: #4479BA; width: 400px; color: #FFFFFF;"|'''Age''' | |||
! style="background: #4479BA; width: 300px; color: #FFFFFF;"|'''Risk Factors''' | |||
! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Prognosis''' | |||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Pulmonary Langerhans cell histiocytosis''' | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Isolated pulmonary involvement | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Adults | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Occurs exclusively among smokers | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Good prognosis with smoking cessation | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Unifocal Langerhans cell histiocytosis''' | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Isolated bone involvement | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |2–10 years of age | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Familial predisposition | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Good prognosis, may spontaneously regress | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Multifocal unisystem Langerhans cell histiocytosis''' | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Triad of diabetes insipidus, exopthalmos, and lytic bone lesions | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |2–10 years of age | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Familial predisposition | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Good prognosis, may spontaneously regress | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Multifocal multisystem Langerhans cell histiocytosis''' | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Involves skin, lungs, bone, and GI tract | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |< 2 years of age | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Familial predisposition | |||
| style="padding: 5px 5px; background: #F5F5F5;" align=center |Poor prognosis | |||
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==References== | ==References== | ||
Revision as of 13:07, 4 February 2016
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Langerhans cell histiocytosis Microchapters |
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Differentiating Langerhans cell histiocytosis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Langerhans cell histiocytosis classification On the Web |
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American Roentgen Ray Society Images of Langerhans cell histiocytosis classification |
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Directions to Hospitals Treating Langerhans cell histiocytosis |
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Risk calculators and risk factors for Langerhans cell histiocytosis classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Classification
- Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.
- The table below lists the features of each specific Langerhans cell histiocytosis subtype:
| Subtype | Organ Involvement | Age | Risk Factors | Prognosis |
|---|---|---|---|---|
| Pulmonary Langerhans cell histiocytosis | Isolated pulmonary involvement | Adults | Occurs exclusively among smokers | Good prognosis with smoking cessation |
| Unifocal Langerhans cell histiocytosis | Isolated bone involvement | 2–10 years of age | Familial predisposition | Good prognosis, may spontaneously regress |
| Multifocal unisystem Langerhans cell histiocytosis | Triad of diabetes insipidus, exopthalmos, and lytic bone lesions | 2–10 years of age | Familial predisposition | Good prognosis, may spontaneously regress |
| Multifocal multisystem Langerhans cell histiocytosis | Involves skin, lungs, bone, and GI tract | < 2 years of age | Familial predisposition | Poor prognosis |