Sandbox: Langerhans: Difference between revisions
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LCH is a rare disease, | |||
affecting approximately 5 to 6 persons per 1 million people annually in the United States | |||
It is primarily encountered in pediatric patients; 50% to 90% of cases are diagnosed between the ages of 1 year and 15 years. | |||
* Langerhans cell histiocytosis commonly affects individuals younger than 15 years of age. | |||
* The median age at diagnosis is depends on the specific subtype of the disease, such as: | |||
:* Pulmonary Langerhans cell histiocytosis is usually first diagnosed among adults. | |||
:* Unifocal Langerhans cell histiocytosis and multifocal unisystem Langerhans cell histiocytosis are usually first diagnosed among individuals of 2-10 years of age. | |||
:* Multifocal multisystem Langerhans cell histiocytosis is usually first diagnosed among individuals younger than 2 years of age. | |||
Patients with isolated EG bone lesions typically present at age 5 to 15 years, whereas those with systemic forms of LCH present earlier (age 1 year to 5 years). | |||
These lesions predominantly affect males, with a male-to-female ratio of 2 to 3:1 reported. | |||
Revision as of 15:07, 4 February 2016
LCH is a rare disease, affecting approximately 5 to 6 persons per 1 million people annually in the United States It is primarily encountered in pediatric patients; 50% to 90% of cases are diagnosed between the ages of 1 year and 15 years.
- Langerhans cell histiocytosis commonly affects individuals younger than 15 years of age.
- The median age at diagnosis is depends on the specific subtype of the disease, such as:
- Pulmonary Langerhans cell histiocytosis is usually first diagnosed among adults.
- Unifocal Langerhans cell histiocytosis and multifocal unisystem Langerhans cell histiocytosis are usually first diagnosed among individuals of 2-10 years of age.
- Multifocal multisystem Langerhans cell histiocytosis is usually first diagnosed among individuals younger than 2 years of age.
Patients with isolated EG bone lesions typically present at age 5 to 15 years, whereas those with systemic forms of LCH present earlier (age 1 year to 5 years).
These lesions predominantly affect males, with a male-to-female ratio of 2 to 3:1 reported.