Extramammary Paget's disease overview: Difference between revisions
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==Overview== | ==Overview== | ||
Extamammary Paget's disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma involving primarily the epidermis but occasionally extending into the underlying dermis. It has predilection for apocrine gland-bearing areas: mostly the perineum, vulva, axilla, scrotum and penis. The origin of the neoplastic cells could be [[apocrine gland]]s or epithelial [[stem cells]]. Extramammary paget's disease may originate in vulvar apocrine-gland bearing skin cells or as a manifestation of adjacent primary rectal, anal, or bladder adenocarcinoma. The most common site of involvement is the vulva, although perianal, perineal, scrotal and penile skin may also be affected. Extramammary Paget disease (empd) is also described as an apocrine gland tumour occurring in both a benign and a malignant form with metastatic potential. It can present as carcinoma in situ or as invasive disease that can subsequently metastasize to lymph nodes and distant sites. | Extamammary Paget's disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma involving primarily the epidermis but occasionally extending into the underlying dermis. It has predilection for apocrine gland-bearing areas: mostly the perineum, vulva, axilla, scrotum and penis. The origin of the neoplastic cells could be [[apocrine gland]]s or epithelial [[stem cells]]. Extramammary paget's disease may originate in vulvar apocrine-gland bearing skin cells or as a manifestation of adjacent primary rectal, anal, or bladder adenocarcinoma. The most common site of involvement is the vulva, although perianal, perineal, scrotal and penile skin may also be affected. Extramammary Paget disease (empd) is also described as an apocrine gland tumour occurring in both a benign and a malignant form with metastatic potential. It can present as carcinoma in situ or as invasive disease that can subsequently metastasize to lymph nodes and distant sites.<ref name="MannLavaf2012">{{cite journal|last1=Mann|first1=J.|last2=Lavaf|first2=A.|last3=Tejwani|first3=A.|last4=Ross|first4=P.|last5=Ashamalla|first5=H.|title=Perianal Paget disease treated definitively with radiotherapy|journal=Current Oncology|volume=19|issue=6|year=2012|issn=11980052|doi=10.3747/co.19.1144}}</ref><ref name="MorettoNair2013">{{cite journal|last1=Moretto|first1=P.|last2=Nair|first2=V.J.|last3=El Hallani|first3=S.|last4=Malone|first4=S.|last5=Belanger|first5=E.|last6=Morash|first6=C.|last7=Canil|first7=C.M.|title=Management of penoscrotal extramammary Paget disease: case series and review of the literature|journal=Current Oncology|volume=20|issue=4|year=2013|pages=311|issn=1718-7729|doi=10.3747/co.20.1353}}</ref><ref name="ShepherdDavidson2005">{{cite journal|last1=Shepherd|first1=Victoria|last2=Davidson|first2=Emma J.|last3=Davies-Humphreys|first3=John|title=Extramammary Paget's disease|journal=BJOG: An International Journal of Obstetrics and Gynaecology|volume=112|issue=3|year=2005|pages=273–279|issn=1470-0328|doi=10.1111/j.1471-0528.2004.00438.x}}</ref><ref name="GuerraMisra2013">{{cite journal|last1=Guerra|first1=Rosa|last2=Misra|first2=Subhasis|title=Management of Extramammary Paget's Disease: A Case Report and Review of the Literature|journal=Case Reports in Dermatological Medicine|volume=2013|year=2013|pages=1–4|issn=2090-6463|doi=10.1155/2013/436390}}</ref><ref name="AsmoukiOumouloud2012">{{cite journal|last1=Asmouki|first1=Hamid|last2=Oumouloud|first2=Rachid|last3=Aboulfalah|first3=Abderrahim|last4=Soummani|first4=Abderraouf|last5=Marrat|first5=Abdelouahed|title=Paget’s Disease of the Vulva in Premenopausal Woman Treated with Only Surgery: A Case Report|journal=Case Reports in Oncological Medicine|volume=2012|year=2012|pages=1–4|issn=2090-6706|doi=10.1155/2012/854827}}</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 15:58, 4 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Extamammary Paget's disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma involving primarily the epidermis but occasionally extending into the underlying dermis. It has predilection for apocrine gland-bearing areas: mostly the perineum, vulva, axilla, scrotum and penis. The origin of the neoplastic cells could be apocrine glands or epithelial stem cells. Extramammary paget's disease may originate in vulvar apocrine-gland bearing skin cells or as a manifestation of adjacent primary rectal, anal, or bladder adenocarcinoma. The most common site of involvement is the vulva, although perianal, perineal, scrotal and penile skin may also be affected. Extramammary Paget disease (empd) is also described as an apocrine gland tumour occurring in both a benign and a malignant form with metastatic potential. It can present as carcinoma in situ or as invasive disease that can subsequently metastasize to lymph nodes and distant sites.[1][2][3][4][5]
References
- ↑ Mann, J.; Lavaf, A.; Tejwani, A.; Ross, P.; Ashamalla, H. (2012). "Perianal Paget disease treated definitively with radiotherapy". Current Oncology. 19 (6). doi:10.3747/co.19.1144. ISSN 1198-0052.
- ↑ Moretto, P.; Nair, V.J.; El Hallani, S.; Malone, S.; Belanger, E.; Morash, C.; Canil, C.M. (2013). "Management of penoscrotal extramammary Paget disease: case series and review of the literature". Current Oncology. 20 (4): 311. doi:10.3747/co.20.1353. ISSN 1718-7729.
- ↑ Shepherd, Victoria; Davidson, Emma J.; Davies-Humphreys, John (2005). "Extramammary Paget's disease". BJOG: An International Journal of Obstetrics and Gynaecology. 112 (3): 273–279. doi:10.1111/j.1471-0528.2004.00438.x. ISSN 1470-0328.
- ↑ Guerra, Rosa; Misra, Subhasis (2013). "Management of Extramammary Paget's Disease: A Case Report and Review of the Literature". Case Reports in Dermatological Medicine. 2013: 1–4. doi:10.1155/2013/436390. ISSN 2090-6463.
- ↑ Asmouki, Hamid; Oumouloud, Rachid; Aboulfalah, Abderrahim; Soummani, Abderraouf; Marrat, Abdelouahed (2012). "Paget's Disease of the Vulva in Premenopausal Woman Treated with Only Surgery: A Case Report". Case Reports in Oncological Medicine. 2012: 1–4. doi:10.1155/2012/854827. ISSN 2090-6706.