Langerhans cell histiocytosis laboratory tests: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Langerhans cell histiocytosis}} | {{Langerhans cell histiocytosis}} | ||
{{CMG}} | {{CMG}} {{AE}} {{HL}} | ||
==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
====Complete Blood Count==== | |||
====Basic Metabolic Panel==== | |||
====Urinalysis==== | |||
====Immunohistochemistry==== | |||
*Diagnosis of LCH is confirmed [[histologically]] by [[tissue]] [[biopsy]]. | *Diagnosis of LCH is confirmed [[histologically]] by [[tissue]] [[biopsy]]. | ||
*Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific. | *Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific. | ||
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{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Revision as of 20:40, 4 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Laboratory Findings
Complete Blood Count
Basic Metabolic Panel
Urinalysis
Immunohistochemistry
- Diagnosis of LCH is confirmed histologically by tissue biopsy.
- Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular cytoplasm. Presence of Birbeck granules on electron microscopy and immuno-cytochemical features e. g. CD1 positivity are more specific.
- Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.
- Assessment of endocrine function and bone marrow biopsy are also performed when indicated.