Langerhans cell histiocytosis laboratory tests: Difference between revisions
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==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
====Complete Blood Count==== | ====Complete Blood Count==== | ||
* Anemia | |||
* Thrombocytopenia | |||
* Elevated erythrocyte sedimentation rate | |||
====Basic Metabolic Panel==== | ====Basic Metabolic Panel==== | ||
====Urinalysis==== | ====Urinalysis==== |
Revision as of 20:44, 4 February 2016
Langerhans cell histiocytosis Microchapters |
Differentiating Langerhans cell histiocytosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Laboratory Findings
Complete Blood Count
- Anemia
- Thrombocytopenia
- Elevated erythrocyte sedimentation rate
Basic Metabolic Panel
Urinalysis
Immunohistochemistry
- Diagnosis of LCH is confirmed histologically by tissue biopsy.
- Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular cytoplasm. Presence of Birbeck granules on electron microscopy and immuno-cytochemical features e. g. CD1 positivity are more specific.
- Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.
- Assessment of endocrine function and bone marrow biopsy are also performed when indicated.