Extramammary Paget's disease overview: Difference between revisions
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==Secondary Prevention== | ==Secondary Prevention== | ||
Secondary prevention strategies following extramammary Paget's disease include an annual complete physical examination, [[proctosigmoidoscopy]] and [[punch biopsy]] of any new lesion. Colonoscopy should be carried out at every two to three year intervals.<ref name="pmid9336114 [">{{cite journal| author=Sarmiento JM, Wolff BG, Burgart LJ, Frizelle FA, Ilstrup DM| title=Paget's disease of the perianal region--an aggressive disease? | journal=Dis Colon Rectum | year= 1997 | volume= 40 | issue= 10 | pages= 1187-94 | pmid=9336114 [ | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9336114 }} </ref> | Secondary prevention strategies following extramammary Paget's disease include an annual complete physical examination, [[proctosigmoidoscopy]] and [[punch biopsy]] of any new lesion. [[Colonoscopy]] should be carried out at every two to three year intervals.<ref name="pmid9336114 [">{{cite journal| author=Sarmiento JM, Wolff BG, Burgart LJ, Frizelle FA, Ilstrup DM| title=Paget's disease of the perianal region--an aggressive disease? | journal=Dis Colon Rectum | year= 1997 | volume= 40 | issue= 10 | pages= 1187-94 | pmid=9336114 [ | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9336114 }} </ref> | ||
==References== | ==References== | ||
Revision as of 18:38, 5 February 2016
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Extramammary Paget's disease Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Extamammary Paget's disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma involving primarily the epidermis but occasionally extending into the underlying dermis. It has predilection for apocrine gland-bearing areas: mostly the perineum, vulva, axilla, scrotum and penis. The origin of the neoplastic cells could be apocrine glands or epithelial stem cells. Extramammary paget's disease may originate in vulvar apocrine-gland bearing skin cells or as a manifestation of adjacent primary rectal, anal, or bladder adenocarcinoma. The most common site of involvement is the vulva, although perianal, perineal, scrotal and penile skin may also be affected. Extramammary Paget disease (empd) is also described as an apocrine gland tumour occurring in both a benign and a malignant form with metastatic potential. It can present as carcinoma in situ or as invasive disease that can subsequently metastasize to lymph nodes and distant sites.[1][2][3][4][5] Extramammary Paget's disease was first discovered by Radcliffe Crocker, in 1889.[6] Extramammary Paget's disease may be classified into two groups based on the origin of the Paget's cells. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected.[7] On gross pathology, plaque with an irregular border and erythematous or white lesion are characteristic findings of extramammary Paget's disease. On microscopic histopathological analysis, Paget's cells which are large cells with abundant amphophilic or basophilic, finely granular cytoplasm, the nucleus which is usually large, centrally situated, and sometimes contains a prominent nucleolus, and signet ring cells are characteristic findings of extramammary Paget's disease. Extramammary Paget's disease arises from keratinocytic stem cells or from apocrine gland ducts. Approximately 25% (range, 9-32%) of the cases of EMPD are associated with an underlying in situ or invasive neoplasm. The neoplasm most likely to be associated with EMPD is an adnexal apocrine carcinoma. This associated neoplasm probably represents infiltration of the deeper adnexa by epidermal Paget cells.[8][9] The cause of extramammary Paget's disease has not been identified.[10][11][12][13] Extramammary Paget's disease is rare and the precise incidence is unknown. Extramammary Paget's disease commonly affects individuals 50-60 years of age. Females are more commonly affected with the disease than males. The female to male ratio is approximately 4.5-3 to 1. It usually affects individuals of the Caucasian race, but it may occur in other races.[14] Symptoms of extramammary Paget's disease include pruritis, vulvar pain, vulvar bleeding, and burning sensation.[15][16][17] Biopsy is diagnostic of extramammary Paget's disease. Other diagnostic studies for extramammary Paget's disease include fine needle aspirate and PAP smear. Other imaging studies for EMPD include bone scan, ultrasound scan, PET scan, cystoscopy, sigmoidoscopy, colonoscopy, mammography, and colposcopy, which demonstrates metastases and underlying invasive carcinomas.[14][18]
Historical Perspective
Extramammary Paget's disease was first discovered by Radcliffe Crocker, in 1889.[6]
Classification
Extramammary Paget's disease may be classified into two groups based on the origin of the Paget's cells. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected.[7]
Pathophysiology
On gross pathology, plaque with an irregular border and erythematous or white lesion are characteristic findings of extramammary Paget's disease. On microscopic histopathological analysis, Paget's cells which are large cells with abundant amphophilic or basophilic, finely granular cytoplasm, the nucleus which is usually large, centrally situated, and sometimes contains a prominent nucleolus, and signet ring cells are characteristic findings of extramammary Paget's disease. Extramammary Paget's disease arises from keratinocytic stem cells or from apocrine gland ducts. Approximately 25% (range, 9-32%) of the cases of EMPD are associated with an underlying in situ or invasive neoplasm. The neoplasm most likely to be associated with EMPD is an adnexal apocrine carcinoma. This associated neoplasm probably represents infiltration of the deeper adnexa by epidermal Paget cells.[8][9]
Causes
The cause of extramammary Paget's disease has not been identified.[19][11][20][13]
Differential Diagnosis
Extramammary Paget's disease must be differentiated from basal cell carcinoma, Bowen's disease, cutaneous candidiasis, intertrigo, irritant contact dermatitis, lichen simplex chronicus, plaque psoriasis, tinea cruris, seborrhoeic dermatitis, lichen sclerosis, anogenital intraepithelial neoplasia, melanoma, histiocytosis, mycosis fungoides, leukoplakia, squamous cell carcinoma, condylomata accuminata, Crohn's disease, and hidradenitis suppurativa.[21]
Epidemiology and Demographics
Extramammary Paget's disease is rare and the precise incidence is unknown. Extramammary Paget's disease commonly affects individuals 50-60 years of age. Females are more commonly affected with the disease than males. The female to male ratio is approximately 4.5-3 to 1. It usually affects individuals of the Caucasian race, but it may occur in other races.[14]
Risk Factors
There are no established risk factors for extramammary Paget's disease.
Screening
According to the United States Preventive Services Task Force, screening for extramammary Paget's disease is not recommended.[22]
Natural History, Complications and Prognosis
If left untreated, the disease always takes a progressive course with no spontaneous recovery. Common complications of extramammary Paget's disease include recurrence of the tumor. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. The prognosis for primary Extramammary Pagets's disease (EMPD) confined to the epidermis is excellent. However, invasive primary extramammary Paget's disease (EMPD) carries a poor prognosis, particularly if lymphovascular invasion is present.[23][24][25][11][1][2]
History and Symptoms
Symptoms of extramammary Paget's disease include pruritis, vulvar pain, vulvar bleeding, and burning sensation.[15][16][17]
Physical Examination
Common physical examination findings of extramammary Paget's disease include well demarcated, erythematous or leucoplakic plaques present on the skin, characteristic ‘cake-icing’ appearance of vulval extramammary Paget's disease, consisting of erythematous changes associated with white islands and bridges of hyperkeratotic epithelium, and lymphadenopathy.[26][27]
Chest X Ray
Chest x-rays may be performed to detect metastases of extramammary Paget's disease to the lungs.
CT
Chest, abdomen, and pelvic CT scan may be helpful in the diagnosis of extramammary Paget's disease. CT scan can confirm the exact location of the cancer and show the organs nearby, as well as lymph nodes and distant organs where the cancer might have spread.
MRI
Chest, abdomen, and pelvic MRI scan may be helpful in the diagnosis of EMPD.
Other Imaging Findings
Other imaging studies for EMPD include bone scan, ultrasound scan, PET scan, cystoscopy, sigmoidoscopy, colonoscopy, mammography, and colposcopy, which demonstrates metastases and underlying invasive carcinomas.[14][18]
Other Diagnostic Studies
Biopsy is diagnostic of extramammary Paget's disease. Other diagnostic studies for extramammary Paget's disease include fine needle aspirate and PAP smear.
Medical Therapy
Surgery
Primary Prevention
Biopsy is diagnostic of extramammary Paget's disease. Other diagnostic studies for extramammary Paget's disease include fine needle aspirate and PAP smear.
Secondary Prevention
Secondary prevention strategies following extramammary Paget's disease include an annual complete physical examination, proctosigmoidoscopy and punch biopsy of any new lesion. Colonoscopy should be carried out at every two to three year intervals.[28]
References
- ↑ 1.0 1.1 Mann, J.; Lavaf, A.; Tejwani, A.; Ross, P.; Ashamalla, H. (2012). "Perianal Paget disease treated definitively with radiotherapy". Current Oncology. 19 (6). doi:10.3747/co.19.1144. ISSN 1198-0052.
- ↑ 2.0 2.1 Moretto, P.; Nair, V.J.; El Hallani, S.; Malone, S.; Belanger, E.; Morash, C.; Canil, C.M. (2013). "Management of penoscrotal extramammary Paget disease: case series and review of the literature". Current Oncology. 20 (4): 311. doi:10.3747/co.20.1353. ISSN 1718-7729.
- ↑ Shepherd, Victoria; Davidson, Emma J.; Davies-Humphreys, John (2005). "Extramammary Paget's disease". BJOG: An International Journal of Obstetrics and Gynaecology. 112 (3): 273–279. doi:10.1111/j.1471-0528.2004.00438.x. ISSN 1470-0328.
- ↑ Guerra, Rosa; Misra, Subhasis (2013). "Management of Extramammary Paget's Disease: A Case Report and Review of the Literature". Case Reports in Dermatological Medicine. 2013: 1–4. doi:10.1155/2013/436390. ISSN 2090-6463.
- ↑ Asmouki, Hamid; Oumouloud, Rachid; Aboulfalah, Abderrahim; Soummani, Abderraouf; Marrat, Abdelouahed (2012). "Paget's Disease of the Vulva in Premenopausal Woman Treated with Only Surgery: A Case Report". Case Reports in Oncological Medicine. 2012: 1–4. doi:10.1155/2012/854827. ISSN 2090-6706.
- ↑ 6.0 6.1 extramammary Paget's disease. Wikipedia(2015) https://en.wikipedia.org/wiki/Extramammary_Paget%27s_disease Accessed on January 26, 2016
- ↑ 7.0 7.1 Wilkinson EJ, Brown HM (2002). "Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease". Hum Pathol. 33 (5): 549–54. PMID 12094382.
- ↑ 8.0 8.1 Roy J, Mirnezami A, Gatt M, Sasapu KK, Scott N, Sagar PM (2010). "A rare case of Paget's disease in a retrorectal dermoid cyst". Colorectal Dis. 12 (9): 946–7. doi:10.1111/j.1463-1318.2009.02102.x. PMID 19888952.
- ↑ 9.0 9.1 Ameloblastoma. Libre pathology(2015) http://librepathology.org/wiki/index.php/Extramammary_Paget_disease#Microscopic Accessed on January 30, 2016
- ↑ Lever, Walter F., and David E. Elder. Lever's histopathology of the skin. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2009.
- ↑ 11.0 11.1 11.2 Lloyd J, Flanagan AM (2000). "Mammary and extramammary Paget's disease". J Clin Pathol. 53 (10): 742–9. PMC 1731095. PMID 11064666.
- ↑ Mehregan, Amir H., and Hermann Pinkus. Pinkus' guide to dermatohistopathology. Norwalk, Conn: Appleton-Century-Crofts, 1986. Print.
- ↑ 13.0 13.1 Orlandi, A.; Piccione, E.; Francesconi, A.; Spagnoli, L. G. (2001). "Simultaneous vulvar intraepithelial neoplasia and Paget's disease: Report of two cases". International Journal of Gynecological Cancer. 11 (3): 224–228. doi:10.1046/j.1525-1438.2001.01016.x. ISSN 1048-891X.
- ↑ 14.0 14.1 14.2 14.3 Chanda JJ (1985). "Extramammary Paget's disease: prognosis and relationship to internal malignancy". J Am Acad Dermatol. 13 (6): 1009–14. PMID 3001158.
- ↑ 15.0 15.1 Zollo, J.D.; Zeitouni, N.C. (2000). "The Roswell Park Cancer Institute experience with extramammary Paget's disease". British Journal of Dermatology. 142 (1): 59–65. doi:10.1046/j.1365-2133.2000.03242.x. ISSN 0007-0963.
- ↑ 16.0 16.1 Parker LP, Parker JR, Bodurka-Bevers D, Deavers M, Bevers MW, Shen-Gunther J; et al. (2000). "Paget's disease of the vulva: pathology, pattern of involvement, and prognosis". Gynecol Oncol. 77 (1): 183–9. doi:10.1006/gyno.2000.5741. PMID 10739709.
- ↑ 17.0 17.1 Tebes S, Cardosi R, Hoffman M (2002). "Paget's disease of the vulva". Am J Obstet Gynecol. 187 (2): 281–3, discussion 283-4. PMID 12193912.
- ↑ 18.0 18.1 Cho SB, Yun M, Lee MG, Chung KY (2005). "Variable patterns of positron emission tomography in the assessment of patients with extramammary Paget's disease". J Am Acad Dermatol. 52 (2): 353–5. doi:10.1016/j.jaad.2004.10.864. PMID 15692486.
- ↑ Lever, Walter F., and David E. Elder. Lever's histopathology of the skin. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2009.
- ↑ Mehregan, Amir H., and Hermann Pinkus. Pinkus' guide to dermatohistopathology. Norwalk, Conn: Appleton-Century-Crofts, 1986. Print.
- ↑ Balducci L, Crawford ED, Smith GF, Lambuth B, McGehee R, Hardy C (1988). "Extramammary Paget's disease: an annotated review". Cancer Invest. 6 (3): 293–303. PMID 2844363.
- ↑ http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=extramammary+pagets+disease Accessed on January 26, 2016.
- ↑ Goldblum JR, Hart WR (1997). "Vulvar Paget's disease: a clinicopathologic and immunohistochemical study of 19 cases". Am J Surg Pathol. 21 (10): 1178–87. PMID 9331290.
- ↑ Goldblum JR, Hart WR (1998). "Perianal Paget's disease: a histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma". Am J Surg Pathol. 22 (2): 170–9. PMID 9500217.
- ↑ DeVita, Vincent T., Theodore S. Lawrence, and Steven A. Rosenberg. DeVita, Hellman, and Rosenberg's cancer : principles & practice of oncology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2011. Print.
- ↑ Heymann WR (1993). "Extramammary Paget's disease". Clin Dermatol. 11 (1): 83–7. PMID 8393362.
- ↑ Silverberg, Steven G., and Ronald A. DeLellis. Silverberg's principles and practice of surgical pathology and cytopathology. Edinburgh: Churchill Livingstone/Elsevier, 2006. Print.
- ↑ Sarmiento JM, Wolff BG, Burgart LJ, Frizelle FA, Ilstrup DM (1997). "Paget's disease of the perianal region--an aggressive disease?". Dis Colon Rectum. 40 (10): 1187–94. PMID [ 9336114 [ Check
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