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==Overview==
==Overview==
The [[diagnosis]] of brucellosis is based on [[clinical]] and [[laboratory]] [[criteria]].<ref name="e">Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016</ref>  
The diagnosis of brucellosis is based on clinical and laboratory criteria.<ref name="e">Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016</ref>  


==Diagnostic Criteria==
==Diagnostic Criteria==
*'''Clinical Description'''
**An [[illness]] characterized by [[Acute (medical)|acute]] or insidious onset of [[fever]] and one or more of the following:
***[[Night sweats]]
***[[Arthralgia]]
***[[Headache]]
***[[Fatigue]]
***[[Anorexia]]
***[[Myalgia]]
***[[Weight loss]]
***[[Arthritis]]/[[spondylitis]]
***[[Meningitis]]
***Focal organ involvement ([[endocarditis]], [[orchitis]]/[[epididymitis]], [[hepatomegaly]], [[splenomegaly]])
*'''Laboratory Criteria for Diagnosis'''
**''Definitive:''
***[[Culture media|Culture]] and identification of [[Brucella|''Brucella spp'']]. from clinical specimens
***Evidence of a fourfold or greater rise in [[Brucella]] [[antibody]] titer between [[Acute (medicine)|acute]]- and [[convalescent]]-phase serum specimens obtained greater than or equal to 2 weeks apart
**''Presumptive:''
***[[Brucella]] total [[antibody]] titer of greater than or equal to 160 by standard tube agglutination test (SAT) or Brucella microagglutination test (BMAT) in one or more [[serum]] specimens obtained after onset of [[symptoms]]
***Detection of Brucella DNA in a clinical specimen by PCR assay


'''Case Classification'''
=== '''Clinical Description''' ===
*''Probable''
*An illness characterized by acute or insidious onset of [[fever]] and one or more of the following:  
**A clinically compatible [[illness]] with at least one of the following:
**[[Night sweats]]
***[[Epidemiology|Epidemiologically]] linked to a confirmed [[human]] or [[Animals|animal]] brucellosis case
**[[Arthralgia]]
***Presumptive [[laboratory]] evidence, but without definitive [[laboratory]] evidence, of [[Brucella]] [[infection]]
**[[Headache]]
*''Confirmed''
**[[Fatigue]]
**A clinically compatible [[illness]] with definitive [[laboratory]] evidence of [[Brucella]] [[infection]]<ref name="e">Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016</ref>  
**[[Anorexia]]
**[[Myalgia]]
**[[Weight loss]]
**[[Arthritis]]/[[spondylitis]]
**[[Meningitis]]
**Focal organ involvement ([[endocarditis]], [[orchitis]]/[[epididymitis]], [[hepatomegaly]], [[splenomegaly]])
 
=== '''Laboratory Criteria for Diagnosis''' ===
*'''Definitive:'''
**Culture and identification of [[Brucella|''Brucella spp'']]. from clinical specimens
**Evidence of a fourfold or greater rise in [[Brucella|''Brucella'']] antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart
*'''Presumptive:'''
**[[Brucella|''Brucella'']] total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or [[Brucella|''Brucella'']] microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms
**Detection of [[Brucella|''Brucella'']] DNA in a clinical specimen by PCR assay
 
== '''Case Classification''' ==
 
=== Probable ===
*A clinically compatible illness with at least one of the following:
**Epidemiologically linked to a confirmed human or animal brucellosis case
**Presumptive laboratory evidence, but without definitive laboratory evidence, of [[Brucella|''Brucella'']] infection
 
=== Confirmed ===
*A clinically compatible illness with definitive laboratory evidence of [[Brucella|''Brucella'']] infection<ref name="e">Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016</ref>  


==Reference==
==Reference==

Revision as of 13:53, 9 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Danitza Lukac

Overview

The diagnosis of brucellosis is based on clinical and laboratory criteria.[1]

Diagnostic Criteria

Clinical Description

Laboratory Criteria for Diagnosis

  • Definitive:
    • Culture and identification of Brucella spp. from clinical specimens
    • Evidence of a fourfold or greater rise in Brucella antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart
  • Presumptive:
    • Brucella total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or Brucella microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms
    • Detection of Brucella DNA in a clinical specimen by PCR assay

Case Classification

Probable

  • A clinically compatible illness with at least one of the following:
    • Epidemiologically linked to a confirmed human or animal brucellosis case
    • Presumptive laboratory evidence, but without definitive laboratory evidence, of Brucella infection

Confirmed

  • A clinically compatible illness with definitive laboratory evidence of Brucella infection[1]

Reference

  1. ↑ 1.0 1.1 Brucellosis 2010 Case Definition. CDC. http://wwwn.cdc.gov/nndss/conditions/brucellosis/case-definition/2010/. Accessed on February 2, 2016
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