Borrelia mayonii

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This page is about microbiologic aspects of the organism(s).  For clinical aspects of the disease, see Lyme disease.

To learn more about Borrelia burgdorferi, click here Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Historical Perspective

• February 2016 - The first description of Lyme disease caused by B. mayonii among 6 patients from Minnesota, Wisconsin, and North Dakota. The discovery was made when 6 samples (5 blood and 1 synovial fluid) out of approximately 9,000 samples suspected to have Lyme disease between 2012 and 2014 were found to contain bacteria that were genetically distinct from B. burgdorferi.
• The term mayonii refers to the Mayo Clinic medical center in Minnesota, where genetic testing for the organism was first conducted.

Associated Disease

• B. mayonii is thought to cause Lyme disease.

Differentiating B. mayonii from B. burgdorferi

The following table demonstrates key clinical and epidemiological features that distinguish B. mayonii from B. burgdorferi

	B. burgdorferi	B. mayonii
Transmission	Tick bite	Tick bite
Distribution in the USA	Northeast, Mid-Atlantic, and Midwest regions	Midwest region
Bacteria Concentration in Blood (Spirochetemia)	Lower	Higher
Early Symptoms	Fever, headache, rash, neck pain	Fever, headache, rash, neck pain
Late Symptoms	Arthritis	Arthritis
Nausea / Vomiting?	No	Yes
Rash Characteristics	Bull's-eye target lesion	Diffuse rash
Diagnosis	Serology or PCR	Serology or PCR