Extranodal NK-T-cell lymphoma pathophysiology: Difference between revisions
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==Genetics== | ==Genetics== | ||
===Immunotype=== | ===Immunotype=== | ||
The immunophenotype of NK lymphoma cells is classically positive for [[CD2]], [[CD56]], and cytoplasmic [[CD3]] epsilon. They are negative for surface [[CD3]]. Unlike normal NK cells, the tumor cells are usually negative for [[CD7]] and [[CD16]]. They express cytotoxic granule associated proteins [[granzyme B]], T-cell restricted intracellular antigen (TIA-1), and [[perforin]]. | * The immunophenotype of NK lymphoma cells is classically positive for [[CD2]], [[CD56]], and cytoplasmic [[CD3]] epsilon. | ||
* They are negative for surface [[CD3]]. Unlike normal NK cells, the tumor cells are usually negative for [[CD7]] and [[CD16]]. | |||
* They express cytotoxic granule associated proteins [[granzyme B]], T-cell restricted intracellular antigen (TIA-1), and [[perforin]]. | |||
==Gross Pathology== | ==Gross Pathology== | ||
* On gross pathology, | * On gross pathology, anglocentric and angiodestructive pattern of growth with associated geographical [[necrosis]] and [[ulceration]] are characteristic findings of extranodal NK-T-cell lymphoma. | ||
* [[Coagulative necrosis]] and [[apoptotic | * [[Coagulative necrosis]] and [[apoptotic]] bodies are frequently encountered. | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
* On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of | * On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of non-neoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma. | ||
* The tumor cells are small to medium in size with occasional large and anaplastic forms. | * The tumor cells are small to medium in size with occasional large and anaplastic forms. | ||
* The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small lymphocytes, plasma cells, histiocytes, and eosinophils. | * The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small [[lymphocytes]], [[plasma cells]], [[histiocytes]], and [[eosinophils]]. | ||
Revision as of 15:18, 18 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
On gross pathology, anglocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of [disease name]. On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of nonneoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
Genetics
Immunotype
- The immunophenotype of NK lymphoma cells is classically positive for CD2, CD56, and cytoplasmic CD3 epsilon.
- They are negative for surface CD3. Unlike normal NK cells, the tumor cells are usually negative for CD7 and CD16.
- They express cytotoxic granule associated proteins granzyme B, T-cell restricted intracellular antigen (TIA-1), and perforin.
Gross Pathology
- On gross pathology, anglocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of extranodal NK-T-cell lymphoma.
- Coagulative necrosis and apoptotic bodies are frequently encountered.
Microscopic Pathology
- On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of non-neoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
- The tumor cells are small to medium in size with occasional large and anaplastic forms.
- The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small lymphocytes, plasma cells, histiocytes, and eosinophils.