Primary central nervous system lymphoma epidemiology and demographics: Difference between revisions

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The incidence of PCNSL in the immunocompetent population has been reported to have increased more than 10-fold from 2.5 cases to 30 cases per 10 million population<ref>Eby NL, Grufferman S, Flannelly CM, Schold SC, Jr., Vogel FS, Burger PC. Increasing incidence of primary brain lymphoma in the US. ''Cancer'' 1988;62(11):2461-2465</ref><ref>Corn BW, Marcus SM, Topham A, Hauck W, Curran WJ, Jr. Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000? ''Cancer'' 1997;79(12):2409-2413</ref>.  The cause for the increase in incidence of this disease in the immunocompetent population is unknown.
The incidence of PCNSL in the immunocompetent population has been reported to have increased more than 10-fold from 2.5 cases to 30 cases per 10 million population<ref>Eby NL, Grufferman S, Flannelly CM, Schold SC, Jr., Vogel FS, Burger PC. Increasing incidence of primary brain lymphoma in the US. ''Cancer'' 1988;62(11):2461-2465</ref><ref>Corn BW, Marcus SM, Topham A, Hauck W, Curran WJ, Jr. Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000? ''Cancer'' 1997;79(12):2409-2413</ref>.  The cause for the increase in incidence of this disease in the immunocompetent population is unknown.


==Age==
===Age===
Primary central nervous system lymphoma does not have predilections for any age group. In the immunocompetent population, PCNSL typically affects older patients in their 50's and 60's.
*Primary central nervous system lymphoma does not have predilections for any age group.<ref name=pcnslwikipediA1>Primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016</ref>
*The peak incidence is between 60 and 70 years old for immunocompetent patients.<ref name="ManentiDi Giuliano2013">{{cite journal|last1=Manenti|first1=G.|last2=Di Giuliano|first2=F.|last3=Bindi|first3=A.|last4=Liberto|first4=V.|last5=Funel|first5=V.|last6=Garaci|first6=F. G.|last7=Floris|first7=R.|last8=Simonetti|first8=G.|title=A Case of Primary T-Cell Central Nervous System Lymphoma: MR Imaging and MR Spectroscopy Assessment|journal=Case Reports in Radiology|volume=2013|year=2013|pages=1–5|issn=2090-6862|doi=10.1155/2013/916348}}</ref>
*Young age of the patient should be noted, because it is not typical for primary CNS lymphoma.
*Significant increment of incidence rate over time is associated with increased incidence of [[AIDS]] and advanced age.
 
===Gender===
*Males are more commonly affected with primary central nervous system lymphoma than females. The male to female ratio is approximately 1.5 to 1.<ref name="ManentiDi Giuliano2013">{{cite journal|last1=Manenti|first1=G.|last2=Di Giuliano|first2=F.|last3=Bindi|first3=A.|last4=Liberto|first4=V.|last5=Funel|first5=V.|last6=Garaci|first6=F. G.|last7=Floris|first7=R.|last8=Simonetti|first8=G.|title=A Case of Primary T-Cell Central Nervous System Lymphoma: MR Imaging and MR Spectroscopy Assessment|journal=Case Reports in Radiology|volume=2013|year=2013|pages=1–5|issn=2090-6862|doi=10.1155/2013/916348}}</ref>


==References==
==References==

Revision as of 17:10, 18 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Epidemiology and Demographics

Prevalence

  • Primary central nervous system lymphoma constitutes approximately 3%-4% of all primary brain tumors.[1]
  • Primary CNS lymphoma constitues approximately 1%-2% of all lymphomas.[1]

Incidence

  • The overall incidence rate of primary central nervous system lymphoma is 0.4 cases per 100,000 individuals per year.[1]

The incidence of PCNSL in the immunocompetent population has been reported to have increased more than 10-fold from 2.5 cases to 30 cases per 10 million population[2][3]. The cause for the increase in incidence of this disease in the immunocompetent population is unknown.

Age

  • Primary central nervous system lymphoma does not have predilections for any age group.[4]
  • The peak incidence is between 60 and 70 years old for immunocompetent patients.[1]
  • Young age of the patient should be noted, because it is not typical for primary CNS lymphoma.
  • Significant increment of incidence rate over time is associated with increased incidence of AIDS and advanced age.

Gender

  • Males are more commonly affected with primary central nervous system lymphoma than females. The male to female ratio is approximately 1.5 to 1.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Manenti, G.; Di Giuliano, F.; Bindi, A.; Liberto, V.; Funel, V.; Garaci, F. G.; Floris, R.; Simonetti, G. (2013). "A Case of Primary T-Cell Central Nervous System Lymphoma: MR Imaging and MR Spectroscopy Assessment". Case Reports in Radiology. 2013: 1–5. doi:10.1155/2013/916348. ISSN 2090-6862.
  2. ↑ Eby NL, Grufferman S, Flannelly CM, Schold SC, Jr., Vogel FS, Burger PC. Increasing incidence of primary brain lymphoma in the US. Cancer 1988;62(11):2461-2465
  3. ↑ Corn BW, Marcus SM, Topham A, Hauck W, Curran WJ, Jr. Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in the year 2000? Cancer 1997;79(12):2409-2413
  4. ↑ Primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016


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