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==Overview==
==Overview==
'''Extranodal NK-T-cell lymphoma''' is a type of [[lymphoma]].<ref name="pmid16380410">{{cite journal |author=Lee J, Suh C, Park YH, ''et al'' |title=Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study |journal=J. Clin. Oncol. |volume=24 |issue=4 |pages=612–8 |year=2006 |month=February |pmid=16380410 |doi=10.1200/JCO.2005.04.1384 |url=http://www.jco.org/cgi/pmidlookup?view=long&pmid=16380410}}</ref> <ref name="pmid15963893">{{cite journal |author=Lee J, Park YH, Kim WS, ''et al'' |title=Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy |journal=Eur. J. Cancer |volume=41 |issue=10 |pages=1402–8 |year=2005 |month=July |pmid=15963893 |doi=10.1016/j.ejca.2005.03.010 |url=http://linkinghub.elsevier.com/retrieve/pii/S0959-8049(05)00218-2}}</ref> <ref name="pmid19041057">{{cite journal |author=Lee J, Au WY, Park MJ, ''et al'' |title=Autologous hematopoietic stem cell transplantation in extranodal natural killer/T cell lymphoma: a multinational, multicenter, matched controlled study |journal=Biol. Blood Marrow Transplant. |volume=14 |issue=12 |pages=1356–64 |year=2008 |month=December |pmid=19041057 |doi=10.1016/j.bbmt.2008.09.014 |url=http://linkinghub.elsevier.com/retrieve/pii/S1083-8791(08)00405-9}}</ref>
Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes:  NK cell-derived neoplasms, namely, aggressive NK cell leukemia and extra nodal NK-T-cell lymphoma, nasal type.<ref name=Hindawi>Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016 </ref> Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type and extranodal NK-T-cell lymphoma, extra nasal type.<ref name= canadiancancer>Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 18, 2016 </ref><ref name= BioMedCentral> Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016 </ref>
It is called "extranodal" to emphasize that the location is not in the [[lymph node]]. It is sometimes further qualified as "nasal type".
==Classification==
It can be associated with [[Epstein Barr virus]]. <ref name="pmid11727268">{{cite journal |author=Stadlmann S, Fend F, Moser P, Obrist P, Greil R, Dirnhofer S |title=Epstein-Barr virus-associated extranodal NK/T-cell lymphoma, nasal type of the hypopharynx, in a renal allograft recipient: case report and review of literature |journal=Hum. Pathol. |volume=32 |issue=11 |pages=1264–8 |year=2001 |month=November |pmid=11727268 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0046817701559572}}</ref> <ref name="pmid19033930">{{cite journal |author=Ferenczi K, Summers P, Aubert P, ''et al'' |title=A case of CD30+ nasal natural killer/T-cell lymphoma |journal=Am J Dermatopathol |volume=30 |issue=6 |pages=567–71 |year=2008 |month=December |pmid=19033930 |doi=10.1097/DAD.0b013e318184bc3f |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00000372-200812000-00006}}</ref>
Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes:  NK cell-derived neoplasms, namely, aggressive NK cell leukemia and extra nodal NK-T-cell lymphoma, nasal type.<ref name=Hindawi>Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016 </ref> Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type and extranodal NK-T-cell lymphoma, extra nasal type.<ref name= canadiancancer>Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 18, 2016 </ref><ref name= BioMedCentral> Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016 </ref>
 
[[RNAi]] against [[EBNA1]] has been proposed as a possible treatment. <ref name="pmid18769118">{{cite journal |author=Ian MX, Lan SZ, Cheng ZF, Dan H, Qiong LH |title=Suppression of EBNA1 expression inhibits growth of EBV-positive NK/T cell lymphoma cells |journal=Cancer Biol. Ther. |volume=7 |issue=10 |pages=1602–6 |year=2008 |month=October |pmid=18769118 |doi= |url=http://www.landesbioscience.com/journals/cbt/abstract.php?id=6564}}</ref>


==References==
==References==
{{Reflist|2|}}
{{Reflist|2|}}

Revision as of 16:40, 19 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes: NK cell-derived neoplasms, namely, aggressive NK cell leukemia and extra nodal NK-T-cell lymphoma, nasal type.[1] Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type and extranodal NK-T-cell lymphoma, extra nasal type.[2][3]

Classification

Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes: NK cell-derived neoplasms, namely, aggressive NK cell leukemia and extra nodal NK-T-cell lymphoma, nasal type.[1] Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type and extranodal NK-T-cell lymphoma, extra nasal type.[2][3]

References

  1. ↑ 1.0 1.1 Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016
  2. ↑ 2.0 2.1 Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 18, 2016
  3. ↑ 3.0 3.1 Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016
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