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{{CMG}}; {{AE}} {{SC}} {{MV}}
{{CMG}}; {{AE}} {{SC}} {{MV}}
==Overview==
==Overview==
Non-small cell lung cancer may be classified according to the WHO histological classification system into 3 main types: squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Other less common subtypes, include: adenosquamous lung carcinoma, pulmonary sarcomatoid carcinoma, carcinoid tumors of lung, and carcinomas of the lung of salivary gland type.<ref name="NSCLC"> Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.</ref>
Non-small cell lung cancer may be classified according to the [[World Health Organization|WHO histological classification system]] into 3 main types: [[Squamous cell lung cancer|squamous cell carcinoma]], [[Adenocarcinoma of the lung|lung adenocarcinoma]], and [[Large cell carcinoma of the lung|large cell carcinoma]]. Other less common subtypes, include: adenosquamous lung carcinoma, pulmonary sarcomatoid carcinoma, carcinoid tumors of lung, and carcinomas of the lung of salivary gland type.<ref name="NSCLC">Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.</ref>


==Classification==
==Classification==
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*The table below summarizes the WHO histological classification system for non small cell lung cancer.<ref>{{cite book | last = Travis | first = William | title = Pathology and genetics of tumours of the lung, pleura, thymus, and heart | publisher = IARC Press | location = Lyon | year = 2004 | isbn = 9283224183 }}</ref><ref name="pmid16640802">{{cite journal| author=Raz DJ, He B, Rosell R, Jablons DM| title=Bronchioloalveolar carcinoma: a review. | journal=Clin Lung Cancer | year= 2006 | volume= 7 | issue= 5 | pages= 313-22 | pmid=16640802 | doi=10.3816/CLC.2006.n.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16640802  }} </ref>
*The table below summarizes the WHO histological classification system for non small cell lung cancer.<ref>{{cite book | last = Travis | first = William | title = Pathology and genetics of tumours of the lung, pleura, thymus, and heart | publisher = IARC Press | location = Lyon | year = 2004 | isbn = 9283224183 }}</ref><ref name="pmid16640802">{{cite journal| author=Raz DJ, He B, Rosell R, Jablons DM| title=Bronchioloalveolar carcinoma: a review. | journal=Clin Lung Cancer | year= 2006 | volume= 7 | issue= 5 | pages= 313-22 | pmid=16640802 | doi=10.3816/CLC.2006.n.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16640802  }} </ref>


{|style="border: 0px; font-size: 90%; margin: 3px; width: 1000px" align=center
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px" align="center"
!style="padding: 5px 5px; background: #4479BA; font-weight: bold; text-align:center;" colspan="3"|{{fontcolor|#FFF|''WHO histological classification system'' <br><SMALL>Adapted from WHO/IARC (2006) <ref name="radiowiki">  Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016 </ref></SMALL>}}
! style="padding: 5px 5px; background: #4479BA; font-weight: bold; text-align:center;" colspan="3" |{{fontcolor|#FFF|''WHO histological classification system'' <br><SMALL>Adapted from WHO/IARC (2006) <ref name="radiowiki">  Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016 </ref></SMALL>}}
|valign=top|
| valign="top" |
|+
|+
|-
|-
| style="background: #4479BA; width: 300px;"|{{fontcolor|#FFF|''' Main types'''}}
| style="background: #4479BA; width: 300px;" |{{fontcolor|#FFF|''' Main types'''}}
| style="background: #4479BA; width: 300px;"|{{fontcolor|#FFF|''' Subtypes'''}}
| style="background: #4479BA; width: 300px;" |{{fontcolor|#FFF|''' Subtypes'''}}
| style="background: #4479BA; width: 300px;"|{{fontcolor|#FFF|''' Prevalence'''}}  
| style="background: #4479BA; width: 300px;" |{{fontcolor|#FFF|''' Prevalence'''}}  
|-
|-
|style="padding: 0 5px; background: #DCDCDC"| '''Adenocarcinoma'''
| style="padding: 0 5px; background: #DCDCDC" | '''Adenocarcinoma'''
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Adenocarcinoma, mixed
*Adenocarcinoma, mixed
*Acinar adenocarcinoma         
*Acinar adenocarcinoma         
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*Signet ring adenocarcinoma             
*Signet ring adenocarcinoma             
*Clear cell adenocarcinoma
*Clear cell adenocarcinoma
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*40% of lung cancers
*40% of lung cancers
|-
|-
|style="padding: 0 5px; background: #DCDCDC"| '''Squamous cell carcinoma'''
| style="padding: 0 5px; background: #DCDCDC" | '''Squamous cell carcinoma'''
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Papillary         
*Papillary         
*Clear cell         
*Clear cell         
*Small cell  
*Small cell  
*Basaloid
*Basaloid
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*25% of lung cancers
*25% of lung cancers
|-
|-
|style="padding: 0 5px; background: #DCDCDC"| '''Large cell carcinoma'''
| style="padding: 0 5px; background: #DCDCDC" | '''Large cell carcinoma'''
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Large cell neuroendocrine carcinoma  
*Large cell neuroendocrine carcinoma  
*Basaloid carcinoma  
*Basaloid carcinoma  
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*Clear cell carcinoma
*Clear cell carcinoma
*Large cell carcinoma with rhabdoid phenotype
*Large cell carcinoma with rhabdoid phenotype
|style="padding: 5px 5px; background: #F5F5F5;"|  
| style="padding: 5px 5px; background: #F5F5F5;" |  
*10% of lung cancer
*10% of lung cancer
|-
|-
|style="background: #4479BA; width: 100px; text-align:center;" colspan="3"|{{fontcolor|#FFF|'''Less common types'''}}  
| style="background: #4479BA; width: 100px; text-align:center;" colspan="3" |{{fontcolor|#FFF|'''Less common types'''}}  
|-
|-
|style="padding: 0 5px; background: #DCDCDC" | '''Adenosquamous carcinoma'''
| style="padding: 0 5px; background: #DCDCDC" | '''Adenosquamous carcinoma'''
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*No subtypes
*No subtypes
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Less than 5%
*Less than 5%
|-
|-
|style="padding: 0 5px; background: #DCDCDC" | '''Sarcomatoid carcinoma'''
| style="padding: 0 5px; background: #DCDCDC" | '''Sarcomatoid carcinoma'''
|style="padding: 5px 5px; background: #F5F5F5;"|  
| style="padding: 5px 5px; background: #F5F5F5;" |  
*Pleomorphic carcinoma  
*Pleomorphic carcinoma  
*Spindle cell carcinoma  
*Spindle cell carcinoma  
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*Carcinosarcoma         
*Carcinosarcoma         
*Pulmonary blastoma
*Pulmonary blastoma
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Less than 5%
*Less than 5%
|-
|-
|style="padding: 0 5px; background: #DCDCDC" | '''Carcinoid tumor'''
| style="padding: 0 5px; background: #DCDCDC" | '''Carcinoid tumor'''
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Typical carcinoid         
*Typical carcinoid         
*Atypical carcinoid
*Atypical carcinoid
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Less than 5%
*Less than 5%
|-
|-
|style="padding: 0 5px; background: #DCDCDC" | '''Salivary gland tumor'''
| style="padding: 0 5px; background: #DCDCDC" | '''Salivary gland tumor'''
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Mucoepidermoid carcinoma         
*Mucoepidermoid carcinoma         
*Adenoid cystic carcinoma  
*Adenoid cystic carcinoma  
*Epithelial-myoepithelial carcinoma
*Epithelial-myoepithelial carcinoma
|style="padding: 5px 5px; background: #F5F5F5;"|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Less than 5%
*Less than 5%
|}
|}


==References==
==References==

Revision as of 20:12, 22 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

Non-small cell lung cancer may be classified according to the WHO histological classification system into 3 main types: squamous cell carcinoma, lung adenocarcinoma, and large cell carcinoma. Other less common subtypes, include: adenosquamous lung carcinoma, pulmonary sarcomatoid carcinoma, carcinoid tumors of lung, and carcinomas of the lung of salivary gland type.[1]

Classification

  • There are 3 main types of non–small cell lung cancer: adenocarcinoma, squamous cell carcinoma and large cell carcinoma.
  • The table below summarizes the WHO histological classification system for non small cell lung cancer.[2][3]
WHO histological classification system
Adapted from WHO/IARC (2006) [4]
Main types Subtypes Prevalence
Adenocarcinoma
  • Adenocarcinoma, mixed
  • Acinar adenocarcinoma
  • Papillary adenocarcinoma
  • Bronchioloalveolar carcinoma
  • Nonmucinous
  • Mucinous
  • Mixed nonmucinous and mucinous or indeterminate
  • Solid adenocarcinoma with mucin production
  • Fetal adenocarcinoma
  • Mucinous (“colloid”) carcinoma
  • Mucinous cystadenocarcinoma
  • Signet ring adenocarcinoma
  • Clear cell adenocarcinoma
  • 40% of lung cancers
Squamous cell carcinoma
  • Papillary
  • Clear cell
  • Small cell
  • Basaloid
  • 25% of lung cancers
Large cell carcinoma
  • Large cell neuroendocrine carcinoma
  • Basaloid carcinoma
  • Lymphoepithelioma-like carcinoma
  • Clear cell carcinoma
  • Large cell carcinoma with rhabdoid phenotype
  • 10% of lung cancer
Less common types
Adenosquamous carcinoma
  • No subtypes
  • Less than 5%
Sarcomatoid carcinoma
  • Pleomorphic carcinoma
  • Spindle cell carcinoma
  • Giant cell carcinoma
  • Carcinosarcoma
  • Pulmonary blastoma
  • Less than 5%
Carcinoid tumor
  • Typical carcinoid
  • Atypical carcinoid
  • Less than 5%
Salivary gland tumor
  • Mucoepidermoid carcinoma
  • Adenoid cystic carcinoma
  • Epithelial-myoepithelial carcinoma
  • Less than 5%

References

  1. ↑ Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.
  2. ↑ Travis, William (2004). Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press. ISBN 9283224183.
  3. ↑ Raz DJ, He B, Rosell R, Jablons DM (2006). "Bronchioloalveolar carcinoma: a review". Clin Lung Cancer. 7 (5): 313–22. doi:10.3816/CLC.2006.n.012. PMID 16640802.
  4. ↑ Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016


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