Mucinous cystadenocarcinoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Pathogenesis

• Mucinous cystadenocarcinoma of the ovary is a rare malignant ovarian mucinous tumor. This type can account for 5-10% of all ovarian mucinous tumors. It is a type of ovarian epithelial tumor.
• Retrospective studies have suggested that many mucinous carcinomas initially diagnosed as primary to the ovary have in fact metastasised from another site.

Associated Conditions

• Malignant transformation of a mature cystic teratoma

Gross Pathology

Features:

Multiloculated. Sticky, gelatinous fluid (glycoprotein). +/-Necrosis. Typically unilateral.[3]

Microscopic Pathology

Features:

Mucinous differentiation. Tall columnar cells in glands with apical mucin. May have an endocervical-like or intestinal-like appearance - see subtypes. Invasive morphology - one of the following: Back-to-back glands/confluent growth pattern. Desmoplastic stromal response. Cribriforming of glands. Malignant characteristics: +/-Nuclear atypia. +/-Necrosis. No cilia.