Non small cell lung cancer natural history: Difference between revisions
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==Natural History== | ==Natural History== | ||
* Most patients with non-small cell lung cancer are initially asymptomatic. | * Most patients with non-small cell lung cancer are initially asymptomatic. | ||
* The symptoms of non-small cell lung cancer usually develop in the fourth and sixth decade of life, and initially patients complain of chronic cough, diaphoresis, and weight-loss. | * The symptoms of non-small cell lung cancer usually develop in the fourth and sixth decade of life, and initially patients complain of [[Cough|chronic cough]], [[diaphoresis]], and [[weight-loss]]. | ||
* If left untreated, patients with non-small cell lung cancer may develop malignant pleural effusion, acute respiratory failure, pneumonia, respiratory acidosis, and distant organ metastases. | * If left untreated, patients with non-small cell lung cancer may develop malignant pleural effusion, [[Respiratory failure|acute respiratory failure]], [[pneumonia]], [[Respiratory acidosis causes|respiratory acidosis]], and distant organ [[metastases]]. | ||
==Complications== | ==Complications== | ||
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==Prognosis== | ==Prognosis== | ||
* Non-small cell lung cancer prognosis is generally regarded as poor, with an all-stage 5% survival rate of 52%. | * Non-small cell lung cancer prognosis is generally regarded as poor, with an all-stage 5% [[survival rate]] of 52%. | ||
* The recurrence rate of non-small cell lung cancer is 24% | * The recurrence rate of non-small cell lung cancer is 24% | ||
* The prognosis for malignant transformation of non-small cell lung cancer will depend on the histological grade, such as: | * The prognosis for malignant transformation of non-small cell lung cancer will depend on the histological grade, such as: | ||
'''Non–small cell lung cancer survival rate by stage'''<ref>Lung cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/lung/prognosis-and-survival/survival-statistics/?region=ab </ref> | '''Non–small cell lung cancer survival rate by stage'''<ref>Lung cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/lung/prognosis-and-survival/survival-statistics/?region=ab </ref> | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
Revision as of 21:32, 23 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]
Overview
If left untreated, patients with non-small cell lung cancer may progress to develop metastases to adjacent lymph nodes or distant organ metastases to liver, bones (spine), or brain. Common complications of non-small cell lung cancer include malignant pleural effusion, acute respiratory failure, and pneumonia. Prognosis is generally regarded as poor with an all-stage average survival rate of 50%. The 5-year recurrence rate of non-small cell lung cancer is 24%.[1]
Natural History
- Most patients with non-small cell lung cancer are initially asymptomatic.
- The symptoms of non-small cell lung cancer usually develop in the fourth and sixth decade of life, and initially patients complain of chronic cough, diaphoresis, and weight-loss.
- If left untreated, patients with non-small cell lung cancer may develop malignant pleural effusion, acute respiratory failure, pneumonia, respiratory acidosis, and distant organ metastases.
Complications
- Common complications of non-small cell lung cancer, include:
- Acute respiratory failure
- Respiratory acidosis
- Malignant pleural effusion
- Metastases
- Pneumonia
Prognosis
- Non-small cell lung cancer prognosis is generally regarded as poor, with an all-stage 5% survival rate of 52%.
- The recurrence rate of non-small cell lung cancer is 24%
- The prognosis for malignant transformation of non-small cell lung cancer will depend on the histological grade, such as:
Non–small cell lung cancer survival rate by stage[2]
| Stage | 5-year survival rate |
|---|---|
| IA | 49% |
| IB | 45% |
| IIA | 30% |
| IIB | 31% |
| IIIA | 14% |
| IIIB | 5% |
| IV | 1% |
References
- ↑ Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E (2007). "Prognosis of lung cancer patients with life-threatening complications". Chest. 131 (3): 840–6. doi:10.1378/chest.06-2244. PMID 17356101.
- ↑ Lung cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/lung/prognosis-and-survival/survival-statistics/?region=ab