Hypergammaglobulinemia pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
Hypergammaglobulinemia is an immunoproliferative disorder with elevated levels of gamma globulin (immunoglobulins or antibodies).<ref>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref><ref>Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.</ref> | Hypergammaglobulinemia is an immunoproliferative disorder with elevated levels of gamma globulin (immunoglobulins or antibodies).<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref><ref>Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.</ref> | ||
==Pathophysiology== | ==Pathophysiology== | ||
*Hypergammaglobulinemia is an immunoproliferative disorder which arises from B cells, which are a type of white cells that are normally involved in the development of humoral immunity by secreting antibodies.<ref>B cell. Wikipedia. https://en.wikipedia.org/wiki/B_cell Accessed on February 24, 2016.</ref> | *Hypergammaglobulinemia is an immunoproliferative disorder which arises from B cells, which are a type of white cells that are normally involved in the development of humoral immunity by secreting antibodies.<ref>B cell. Wikipedia. https://en.wikipedia.org/wiki/B_cell Accessed on February 24, 2016.</ref> | ||
* | *The majority of the hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM) because this is the default immunoglobulin type prior to class switching.<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref> | ||
* | *Hypergammaglobulinemias may also be caused by a deficiency in the other major types of immunoglobulins.<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref><ref>Immunoproliferative disorder. Wikipedia. Accessed on February 24, 2016.</ref> | ||
*The term "hyperglobulinemia" refers to the position of the excess of proteins after serum protein electrophoresis (found in the gammaglobulin region).<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref> | |||
===Type 1 hypergammaglobulinemia=== | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Hypergammaglobulinemia is an immunoproliferative disorder with elevated levels of gamma globulin (immunoglobulins or antibodies).[1][2]
Pathophysiology
- Hypergammaglobulinemia is an immunoproliferative disorder which arises from B cells, which are a type of white cells that are normally involved in the development of humoral immunity by secreting antibodies.[3]
- The majority of the hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM) because this is the default immunoglobulin type prior to class switching.[1]
- Hypergammaglobulinemias may also be caused by a deficiency in the other major types of immunoglobulins.[1][4]
- The term "hyperglobulinemia" refers to the position of the excess of proteins after serum protein electrophoresis (found in the gammaglobulin region).[1]
Type 1 hypergammaglobulinemia
References
- ↑ 1.0 1.1 1.2 1.3 Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.
- ↑ Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.
- ↑ B cell. Wikipedia. https://en.wikipedia.org/wiki/B_cell Accessed on February 24, 2016.
- ↑ Immunoproliferative disorder. Wikipedia. Accessed on February 24, 2016.