Mast cell tumor history and symptoms: Difference between revisions
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*Headache | *Headache | ||
*Dyspnea | *Dyspnea | ||
*Wheezing | *Wheezing*Rhinorrhea | ||
*Rhinorrhea | |||
*Nausea | *Nausea | ||
*Vomiting | *Vomiting | ||
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*Abdominal pain | *Abdominal pain | ||
*Malabsorption | *Malabsorption | ||
*Bone pain and pathological fractures | *Bone pain and pathological fractures | ||
*Weight loss | *Weight loss | ||
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*These lesions urticate in response to physical irritation (Darier’s sign). | *These lesions urticate in response to physical irritation (Darier’s sign). | ||
*Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas. | *Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas. | ||
*The trunk and thigh are more commonly involved with sparing of face, palms and soles. | *The trunk and thigh are more commonly involved with sparing of face, palms and soles. | ||
'''Diffuse Cutaneous Mastocytosis''' | |||
*Diffuse cutaneous mastocytosis is a rare variant of childhood mastocytosis that appears as diffuse infiltrative yellow-orange xanthogranuloma-like subcutaneous nodules, or as a widespread urticarial eruption with bullae and redness. | |||
*The clinical course is more severe and can even be life-threatening, due to hypovolemic shock, mast cell leukemia, gastrointestinal hemorrhage, and cachexia<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref> | |||
==References== | ==References== | ||
Revision as of 21:25, 29 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
There is considerable heterogeneity in the presentation of mastocytosis, and in the rate of disease progression. Clinical features include:[1]
- Pruritic cutaneous lesions
- Flushing
- Headache
- Dyspnea
- Wheezing*Rhinorrhea
- Nausea
- Vomiting
- Diarrhea
- Hypotension and syncope
- Abdominal pain
- Malabsorption
- Bone pain and pathological fractures
- Weight loss
- Fever and night sweats
Urticaria Pigmentosa
- Urticaria pigmentosa is the most common clinical variant in which fixed, reddish brown lesions occurring as maculo-papules, plaques, nodules, or blisters are found.[2]
- These lesions urticate in response to physical irritation (Darier’s sign).
- Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas.
- The trunk and thigh are more commonly involved with sparing of face, palms and soles.
Diffuse Cutaneous Mastocytosis
- Diffuse cutaneous mastocytosis is a rare variant of childhood mastocytosis that appears as diffuse infiltrative yellow-orange xanthogranuloma-like subcutaneous nodules, or as a widespread urticarial eruption with bullae and redness.
- The clinical course is more severe and can even be life-threatening, due to hypovolemic shock, mast cell leukemia, gastrointestinal hemorrhage, and cachexia[2]
References
- ↑ Mastocytosis. Dr Alexandra Stanislavsky. Radiopaedia.org 2015. http://radiopaedia.org/articles/mastocytosis Accessed on February 29, 2016
- ↑ 2.0 2.1 Ferrante, Giuliana; Scavone, Valeria; Muscia, Maria; Adrignola, Emilia; Corsello, Giovanni; Passalacqua, Giovanni; La Grutta, Stefania (2015). "The care pathway for children with urticaria, angioedema, mastocytosis". World Allergy Organization Journal. 8 (1): 5. doi:10.1186/s40413-014-0052-x. ISSN 1939-4551.