Hypergammaglobulinemia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Classification

• Hyper IgM associated hypergammaglobulinemias may be classified into the following five types:

Type	Gene involved	Mode of inheritance
Type 1	Tumor Necrosis Factor Super Family member 5 (TNFSF5) gene encoding CD40L	X-linked recessive
Type 2	Activation-Induced Cytidine Deaminase (AICDA) gene	Autosomal recessive
Type 3	CD40 gene	Autosomal recessive
Type 4	Not yet known
Type 5	Gene encoding Uracil-DNA glycosylase	Autosomal recessive

Related Chapters

• Monoclonal gammopathy of undetermined significance