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*[[Strictures]] or [[fistulas]] of the [[urethra]], [[vagina]], or [[anus]]
*[[Strictures]] or [[fistulas]] of the [[urethra]], [[vagina]], or [[anus]]
*[[Coinfection]] with other [[sexually transmitted infections]] including: [[syphillis]], [[chancroid]], and [[Human Immunodeficiency Virus (HIV)]]
*[[Coinfection]] with other [[sexually transmitted infections]] including: [[syphillis]], [[chancroid]], and [[Human Immunodeficiency Virus (HIV)]]


==Prognosis==
==Prognosis==

Revision as of 21:30, 1 March 2016

Donovanosis Microchapters

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Overview

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Differentiating Donovanosis from other Diseases

Epidemiology and Demographics

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Natural History, Complications and Prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]; Nate Michalak, B.A.

Overview

Natural History

  • The incubation period of Klebsiella granulomatis is debated and ranges from 1 to 360 days with a median time of 50 days.[1]
  • Donovanosis begins with a firm papule or subcutaneous nodule which eventually ulcerates.
  • The ulcer slowly progresses centrifugally to form areas of granulomatous tissue.
  • Ulcers may autoinoculate creating multiple lesions.
  • "Pseudobuboes" may appear, which are nodular lesions that resemble lymphadenopathy.
  • Fibrosis may occur leading to elephantiasis-like swelling.
  • K. granulomatis may disseminate causing extragenital lesions

Complications

Prognosis

  • Treating this disease early decreases the chances of tissue damage or scarring. Untreated disease leads to damage of the genital tissue.

References

  1. Greenblatt, R. B.; Dienst, R. B.; Pund, E. R.; Torpin, Richard (1939). "EXPERIMENTAL AND CLINICAL GRANULOMA INGUINALE". Journal of the American Medical Association. 113 (12): 1109. doi:10.1001/jama.1939.02800370025006. ISSN 0002-9955.

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