Primary cutaneous follicle centre lymphoma pathophysiology: Difference between revisions

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Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:<ref name=cancer.gov> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>
Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:<ref name=cancer.gov> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>
* Amplification of [[C-REL]] gene
* Amplification of [[C-REL]] gene
* [[BCL2]] rearrangements
* [[BCL]]-2 rearrangements


==Gross Pathology==
==Gross Pathology==

Revision as of 13:49, 2 March 2016

Primary cutaneous follicle centre lymphoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Pathophysiology

Genetics

Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:[1]

  • Amplification of C-REL gene
  • BCL-2 rearrangements

Gross Pathology

Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).[2]

Microscopic Pathology

Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).[2]



References

  1. ↑ Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016
  2. ↑ 2.0 2.1 Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7. Accessed on March 01, 2016


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