Donovanosis natural history, complications and prognosis: Difference between revisions
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*Ulcers may autoinoculate creating multiple lesions. | *Ulcers may autoinoculate creating multiple lesions. | ||
*"Pseudobuboes" may appear, which are nodular lesions that resemble [[lymphadenopathy]]. | *"Pseudobuboes" may appear, which are nodular lesions that resemble [[lymphadenopathy]]. | ||
*[[Fibrosis]] may occur leading to [[elephantiasis]]-like swelling. | *[[Fibrosis]] may occur leading to [[elephantiasis]]-like swelling as a result of chronic ulcers. | ||
*''K. granulomatis'' may disseminate causing extragenital lesions | *''K. granulomatis'' may disseminate causing extragenital lesions | ||
Revision as of 14:28, 2 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]; Nate Michalak, B.A.
Overview
Natural History
- The incubation period of Klebsiella granulomatis is debated and ranges from 1 to 360 days with a median time of 50 days.[1]
- Donovanosis begins with a firm papule or subcutaneous nodule which eventually ulcerates.
- The ulcer slowly progresses centrifugally to form areas of granulomatous tissue.
- Ulcers may autoinoculate creating multiple lesions.
- "Pseudobuboes" may appear, which are nodular lesions that resemble lymphadenopathy.
- Fibrosis may occur leading to elephantiasis-like swelling as a result of chronic ulcers.
- K. granulomatis may disseminate causing extragenital lesions
Complications
- Genital damage and scarring
- Elephantiasis-like swelling
- Phimosis in men
- Strictures or fistulas of the urethra, vagina, or anus
- Coinfection with other sexually transmitted infections including: syphillis, chancroid, and Human Immunodeficiency Virus (HIV)
Prognosis
- Treating this disease early decreases the chances of tissue damage or scarring. Untreated disease leads to damage of the genital tissue.
- Donovanosis may reoccur after 6 to 18 months.
References
- ↑ Greenblatt, R. B.; Dienst, R. B.; Pund, E. R.; Torpin, Richard (1939). "EXPERIMENTAL AND CLINICAL GRANULOMA INGUINALE". Journal of the American Medical Association. 113 (12): 1109. doi:10.1001/jama.1939.02800370025006. ISSN 0002-9955.