Mast cell tumor laboratory findings: Difference between revisions
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The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.<ref name="KoenigMorel2008">{{cite journal|last1=Koenig|first1=Martial|last2=Morel|first2=Jérôme|last3=Reynaud|first3=Jacqueline|last4=Varvat|first4=Cécile|last5=Cathébras|first5=Pascal|title=An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report|journal=Cases Journal|volume=1|issue=1|year=2008|pages=100|issn=1757-1626|doi=10.1186/1757-1626-1-100}}</ref> | The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.<ref name="KoenigMorel2008">{{cite journal|last1=Koenig|first1=Martial|last2=Morel|first2=Jérôme|last3=Reynaud|first3=Jacqueline|last4=Varvat|first4=Cécile|last5=Cathébras|first5=Pascal|title=An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report|journal=Cases Journal|volume=1|issue=1|year=2008|pages=100|issn=1757-1626|doi=10.1186/1757-1626-1-100}}</ref> | ||
*Complete blood count | *[[Complete blood count]] | ||
:* | :*[[Eosinophilia]] | ||
:* | :*[[Thrombocytopenia]] | ||
* | *[[Tryptase]] levels | ||
:*Elevated plasma tryptase levels | :*Elevated plasma tryptase levels | ||
*Plasma and urinary histamine | *Plasma and urinary [[histamine]] | ||
:*Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine | :*Chronically elevated plasma and urinary histamine levels and its metabolite [[N-methylhistamine]] | ||
*Partial thromboplastin time | *[[Partial thromboplastin time]] | ||
:*Elevated in a blood sample obtained immediately after attack | :*Elevated in a blood sample obtained immediately after attack | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.[1]
- Tryptase levels
- Elevated plasma tryptase levels
- Plasma and urinary histamine
- Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
- Elevated in a blood sample obtained immediately after attack
References
- ↑ Koenig, Martial; Morel, Jérôme; Reynaud, Jacqueline; Varvat, Cécile; Cathébras, Pascal (2008). "An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report". Cases Journal. 1 (1): 100. doi:10.1186/1757-1626-1-100. ISSN 1757-1626.