Hypergammaglobulinemia overview: Difference between revisions
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==Overview== | ==Overview== | ||
Hypergammaglobulinemia is a [[primary immunodeficiency]] disease with an elevated concentration of [[gamma globulin]]s ([[immunoglobulin]]s or [[antibodies]]).<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref><ref>Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.</ref> The term "hypergammaglobulinemia" refers to the position of the excess of proteins after [[serum protein electrophoresis]] (found in the gammaglobulin region).<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref> The majority of hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM) because this is the default [[immunoglobulin]] type prior to [[class switching]].<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref> Hypergammaglobulinemias may also be caused by a deficiency in the other major types of | Hypergammaglobulinemia is a [[primary immunodeficiency]] disease with an elevated concentration of [[gamma globulin]]s ([[immunoglobulin]]s or [[antibodies]]).<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref><ref>Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.</ref> The term "hypergammaglobulinemia" refers to the position of the excess of proteins after [[serum protein electrophoresis]] (found in the gammaglobulin region).<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref> The majority of hypergammaglobulinemias are caused by an excess of [[immunoglobulin]] M (IgM) because this is the default [[immunoglobulin]] type prior to [[class switching]].<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref> Hypergammaglobulinemias may also be caused by a deficiency in the other major types of [[immunoglobulin]]s.<ref name=kb>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.</ref><ref>Immunoproliferative disorder. Wikipedia. Accessed on February 24, 2016.</ref> | ||
==Classification== | ==Classification== | ||
Revision as of 18:37, 2 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Hypergammaglobulinemia is a primary immunodeficiency disease with an elevated concentration of gamma globulins (immunoglobulins or antibodies).[1][2] The term "hypergammaglobulinemia" refers to the position of the excess of proteins after serum protein electrophoresis (found in the gammaglobulin region).[1] The majority of hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM) because this is the default immunoglobulin type prior to class switching.[1] Hypergammaglobulinemias may also be caused by a deficiency in the other major types of immunoglobulins.[1][3]
Classification
References
- ↑ 1.0 1.1 1.2 1.3 Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.
- ↑ Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.
- ↑ Immunoproliferative disorder. Wikipedia. Accessed on February 24, 2016.