Mast cell tumor laboratory findings: Difference between revisions
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*[[Tryptase]] levels | *[[Tryptase]] levels | ||
:*Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis. | :*Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis. | ||
:* | :*In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels. | ||
*Plasma and urinary [[histamine]] | *Plasma and urinary [[histamine]] | ||
:*Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine | :*Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine | ||
Revision as of 20:31, 2 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.[1]
- Tryptase levels
- Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis.
- In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels.
- Plasma and urinary histamine
- Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
- Elevated in a blood sample obtained immediately after attack
References
- ↑ Koenig, Martial; Morel, Jérôme; Reynaud, Jacqueline; Varvat, Cécile; Cathébras, Pascal (2008). "An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report". Cases Journal. 1 (1): 100. doi:10.1186/1757-1626-1-100. ISSN 1757-1626.