Seminoma pathophysiology: Difference between revisions
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==Gross Pathology== | ==Gross Pathology== | ||
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.<ref name=pathologyoftesticularseminoma1>Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016</ref> | |||
==Microscopic Pathology== | |||
On microscopic pathology, seminoma is characterized by:<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> | |||
*Cells with fried egg appearance - '''key feature''' | |||
:*Clear cytoplasm | |||
:*Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round. | |||
*Lymphoctyes - interspersed (common) | |||
*[[Syncytiotrophoblast]]s, present in ~10-20% of seminoma | |||
:*Large, irregular, vesicular nuclei | |||
:*Eosinophilic vacuolated cytoplasm (contains [[HCG|hCG]]) | |||
*Florid granulomatous reaction | |||
==References== | ==References== | ||
Revision as of 14:15, 3 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Gross Pathology
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]
Microscopic Pathology
On microscopic pathology, seminoma is characterized by:[2]
- Cells with fried egg appearance - key feature
- Clear cytoplasm
- Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.
- Lymphoctyes - interspersed (common)
- Syncytiotrophoblasts, present in ~10-20% of seminoma
- Large, irregular, vesicular nuclei
- Eosinophilic vacuolated cytoplasm (contains hCG)
- Florid granulomatous reaction
References
- ↑ Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
- ↑ Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016