Seminoma pathophysiology: Difference between revisions
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==Microscopic Pathology== | ==Microscopic Pathology== | ||
On microscopic pathology, seminoma is characterized by:<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> | *On microscopic pathology, seminoma is characterized by:<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> | ||
*Cells with fried egg appearance - '''key feature''' | :*Cells with fried egg appearance - '''key feature''' | ||
:*Clear cytoplasm | ::*Clear cytoplasm | ||
:*Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round. | ::*Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round. | ||
*Lymphoctyes - interspersed (common) | :*Lymphoctyes - interspersed (common) | ||
*[[Syncytiotrophoblast]]s, present in ~10-20% of seminoma | :*[[Syncytiotrophoblast]]s, present in ~10-20% of seminoma | ||
:*Large, irregular, vesicular nuclei | ::*Large, irregular, vesicular nuclei | ||
:*Eosinophilic vacuolated cytoplasm (contains [[HCG|hCG]]) | ::*Eosinophilic vacuolated cytoplasm (contains [[HCG|hCG]]) | ||
*Florid granulomatous reaction | :*Florid granulomatous reaction | ||
*Approximately 24% of Stage I seminomas have ''lymphovascular invasion'' for stage I (Tx, N0, M0).<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> | |||
*Intertubular seminoma may not form a discrete mass and mimic a benign testis.<ref name=pathologyofseminoma1>Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016</ref> | |||
==References== | ==References== | ||
Revision as of 14:59, 3 March 2016
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Seminoma Microchapters |
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Diagnosis |
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Seminoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Seminoma pathophysiology |
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Risk calculators and risk factors for Seminoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Gross Pathology
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]
Microscopic Pathology
- On microscopic pathology, seminoma is characterized by:[2]
- Cells with fried egg appearance - key feature
- Clear cytoplasm
- Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.
- Lymphoctyes - interspersed (common)
- Syncytiotrophoblasts, present in ~10-20% of seminoma
- Large, irregular, vesicular nuclei
- Eosinophilic vacuolated cytoplasm (contains hCG)
- Florid granulomatous reaction
- Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0).[2]
- Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2]
References
- ↑ Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
- ↑ 2.0 2.1 2.2 Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016