Seminoma pathophysiology: Difference between revisions
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::*Clear cytoplasm | ::*Clear cytoplasm | ||
::*Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round. | ::*Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round. | ||
:* | :*[[Lymphocytes]] - interspersed (common) | ||
:*[[Syncytiotrophoblast]]s, present in ~10-20% of seminoma | :*[[Syncytiotrophoblast]]s, present in ~10-20% of seminoma | ||
::*Large, irregular, vesicular nuclei | ::*Large, irregular, vesicular nuclei | ||
Revision as of 15:14, 3 March 2016
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Seminoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Seminoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Seminoma pathophysiology |
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Risk calculators and risk factors for Seminoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Gross Pathology
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]
Microscopic Pathology
- On microscopic pathology, seminoma is characterized by:[2]
- Cells with fried egg appearance - key feature
- Clear cytoplasm
- Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.
- Lymphocytes - interspersed (common)
- Syncytiotrophoblasts, present in ~10-20% of seminoma
- Large, irregular, vesicular nuclei
- Eosinophilic vacuolated cytoplasm (contains hCG)
- Florid granulomatous reaction
- Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0).[2]
- Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2]
Gallery
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![Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]](/images/1/1c/800px-Seminoma_high_mag.jpg)
Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]
![Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]](/index.php/File:800px-Seminoma_high_mag.jpg)
References
- ↑ Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
- ↑ 2.0 2.1 2.2 2.3 Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016